Evidence map›Paper›PMID 37108313›Full record

ArticleInternational journal of molecular sciences2023

Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure.

Seth Osei Asiedu, Yash Gupta, Vlad Nicolaescu, Haley Gula, Thomas R Caulfield, Ravi Durvasula, Prakasha Kempaiah, Samuel K Kwofie, Michael D Wilson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Seth Osei AsieduDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box GA 337, Ghana.ORCID 0000-0002-2585-1800
Yash GuptaDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.ORCID 0000-0003-3002-1315
Vlad NicolaescuDepartment of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Haley GulaDepartment of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Thomas R CaulfieldDepartment of Neuroscience, Division of QHS Computational Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1055-3069
Ravi DurvasulaDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Prakasha KempaiahDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.ORCID 0000-0002-2901-0339
Samuel K KwofieDepartment of Biomedical Engineering, School of Engineering, University of Ghana, Legon, Accra P.O. Box 77, Ghana.ORCID 0000-0002-1093-1517
Michael D WilsonDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box GA 337, Ghana.ORCID 0000-0002-6048-8509
Mayo Clinic in Florida · USUniversity of Ghana · GHUniversity of Chicago · USMayo Clinic · US

Funding

Mayo Clinic STARDOM #94551013
6 · The paper itself

Abstract

We have previously shown computationally that Mycolactone (MLN), a toxin produced by

Indexed as

COVID-19Antiviral AgentsHEK293 CellsHumansMacrolidesSARS-CoV-2Antiviral AgentsMacrolidesmycolactoneCOVID-19enveloped virusesfusion proteinMycobacterium ulceransmycolactoneprophylaxisSARS-CoV-2treatmentviral cell entry and exit

Identifiers

PMID37108313
PMCPMC10139166
OpenAlexW4365448827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.