Evidence map›Paper›PMID 37108685›Full record

ArticleInternational journal of molecular sciences2023

A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [

Joanne M Tang, Andrew McClennan, Linshan Liu, Jennifer Hadway, John A Ronald, Justin W Hicks, Lisa Hoffman, Udunna C Anazodo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joanne M TangDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.
Andrew McClennanDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.ORCID 0000-0003-0084-3553
Linshan LiuLawson Health Research Institute, London, ON N6A 4V2, Canada.
Jennifer HadwayLawson Health Research Institute, London, ON N6A 4V2, Canada.
John A RonaldDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.
Justin W HicksDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.ORCID 0000-0003-0269-9364
Lisa HoffmanDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.
Udunna C AnazodoDepartment of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.ORCID 0000-0001-8864-035X
Western University · CALawson Health Research Institute · CA

Funding

CIHR PJT-152990
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by dystrophin loss-notably within muscles and the central neurons system. DMD presents as cognitive weakness, progressive skeletal and cardiac muscle degeneration until pre-mature death from cardiac or respiratory failure. Innovative therapies have improved life expectancy; however, this is accompanied by increased late-onset heart failure and emergent cognitive degeneration. Thus, better assessment of dystrophic heart and brain pathophysiology is needed. Chronic inflammation is strongly associated with skeletal and cardiac muscle degeneration; however, neuroinflammation's role is largely unknown in DMD despite being prevalent in other neurodegenerative diseases. Here, we present an inflammatory marker translocator protein (TSPO) positron emission tomography (PET) protocol for in vivo concomitant assessment of immune cell response in hearts and brains of a dystrophin-deficient mouse model [

Indexed as

CardiomyopathiesMuscular Dystrophy, DuchenneAnimalsDisease Models, AnimalDystrophinMiceMice, Inbred mdxMuscle, SkeletalNeuroinflammatory DiseasesPositron-Emission TomographyDystrophin[18F]FEPPAcardiac inflammationDuchenne muscular dystrophymdx:utrn(+/−) miceneuroinflammationpositron emission tomography (PET)

Identifiers

PMID37108685
PMCPMC10144317
OpenAlexW4366527473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.