Evidence map›Paper›PMID 37110251›Full record

ArticleMicroorganisms2023

The Optimal Effective Concentration Combination (OPECC) as a Novel Method for Evaluating the Effects of Binary Application of Antibacterial Compounds.

Karl-Anton Hiller, Verena Wenzl, Eva-Maria Forster, Fabian Cieplik, Tim Maisch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Optimal effective concentration combinations (OPECCs) for binary application of membrane-targeting antiseptics and TMPyP-mediated antimicrobial photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Karl-Anton HillerDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-4726-9555
Verena WenzlDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, 93053 Regensburg, Germany.
Eva-Maria ForsterDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, 93053 Regensburg, Germany.
Fabian CieplikDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-1750-7380
Tim MaischDepartment of Dermatology, University Hospital Regensburg, 93053 Regensburg, Germany.
University Hospital Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft CI 263/3-1
6 · The paper itself

Abstract

Combination therapies appear to be beneficial for preventing bacterial resistance to antibacterial approaches. The aim of this study was to define and determine an optimal effective concentration combination (OPECC) for binary application of antibacterial compounds. The antiseptics chlorhexidine (CHX), benzalkonium chloride (BAC), and cetylpyridinium chloride (CPC), as well as the antibiotic ciprofloxacin (CIP), were tested against planktonic

Indexed as

antibioticsantisepticsbacterial resistancebinarycheckerboard assaycombination therapyEscherichia colioptimal effective concentration combination (OPECC)synergy

Identifiers

PMID37110251
PMCPMC10143449
OpenAlexW4360854782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.