Evidence map›Paper›PMID 37110348›Full record

ArticleMicroorganisms2023

Blood Biomarkers from the Emergency Department Disclose Severe Omicron COVID-19-Associated Outcomes.

Fiorenza Pennacchia, Eqrem Rusi, Wael Abu Ruqa, Maria Antonella Zingaropoli, Patrizia Pasculli, Giuseppina Talarico, Giuseppe Bruno, Christian Barbato, Antonio Minni, Luigi Tarani and 6 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Fiorenza PennacchiaDepartment of Sensory Organs, Sapienza University of Rome, 00185 Roma, Italy.
Eqrem RusiDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Wael Abu RuqaDepartment of Sensory Organs, Sapienza University of Rome, 00185 Roma, Italy.
Maria Antonella ZingaropoliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Patrizia PasculliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-6678-6865
Giuseppina TalaricoDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3608-087X
Giuseppe BrunoDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6948-7169
Christian BarbatoInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1737-9064
Antonio MinniDepartment of Sensory Organs, Sapienza University of Rome, 00185 Roma, Italy.
Luigi TaraniDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-5958-9364
Gioacchino GalardoMedical Emergency Unit, Sapienza University of Rome, 00185 Roma, Italy.
Francesco PuglieseDepartment of Anesthesiology Critical Care Medicine and Pain Therapy, Sapienza University of Rome, 00185 Roma, Italy.
Marco LucarelliDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-5538-2494
Giampiero FerragutiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-6129-4071
Maria Rosa CiardiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Marco FioreInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6806-9715
Sapienza University of Rome · ITOspedale generale di zona San Camillo Treviso · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince its outbreak, Coronavirus disease 2019 (COVID-19), a life-threatening respiratory illness, has rapidly become a public health emergency with a devastating social impact. Lately, the Omicron strain is considered the main variant of concern. Routine blood biomarkers are, indeed, essential for stratifying patients at risk of severe outcomes, and a huge amount of data is available in the literature, mainly for the previous variants. However, only a few studies are available on early routine biochemical blood biomarkers for Omicron-afflicted patients. Thus, the aim and novelty of this study were to identify routine blood biomarkers detected at the emergency room for the early prediction of severe morbidity and/or mortality.

methods449 COVID-19 patients from Sapienza University Hospital of Rome were divided into four groups: (1) the

resultsANOVA and ROC data showed that high-sensitivity troponin-T (TnT), fibrinogen, glycemia, C-reactive protein, lactate dehydrogenase, albumin, D-dimer myoglobin, and ferritin for both men and women may predict lethal outcomes already at the level of the emergency department.

conclusionsCompared to previous Delta COVID-19 parallel emergency patterns of prediction, Omicron-induced changes in TnT may be considered other early predictors of severe outcomes.

Indexed as

biomarkersblood analysesmorbiditymortalityOmicronSARS-CoV-2variant

Identifiers

PMID37110348
PMCPMC10146633
OpenAlexW4362584330

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.