Evidence map›Paper›PMID 37112661›Full record

ArticleVaccines2023

Myocarditis and Pericarditis following COVID-19 Vaccination in Thailand.

Chayanit Mahasing, Pawinee Doungngern, Rittichai Jaipong, Poonyaporn Nonmuti, Jirapa Chimmanee, Jurai Wongsawat, Thananya Boonyasirinant, Chaisiri Wanlapakorn, Pattranee Leelapatana, Teerapat Yingchoncharoen and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Chayanit MahasingDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Building 10 Floor 3, 88/21 Tiwanon Rd., Nonthaburi 11000, Thailand.ORCID 0000-0002-6023-2124
Pawinee DoungngernDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Building 10 Floor 3, 88/21 Tiwanon Rd., Nonthaburi 11000, Thailand.ORCID 0000-0002-1154-4527
Rittichai JaipongDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Building 10 Floor 3, 88/21 Tiwanon Rd., Nonthaburi 11000, Thailand.
Poonyaporn NonmutiDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Building 10 Floor 3, 88/21 Tiwanon Rd., Nonthaburi 11000, Thailand.
Jirapa ChimmaneeDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Building 10 Floor 3, 88/21 Tiwanon Rd., Nonthaburi 11000, Thailand.
Jurai WongsawatBamrasnaradura Infectious Diseases Institute, Nonthaburi 11000, Thailand.
Thananya BoonyasirinantFaculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Chaisiri WanlapakornFaculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Pattranee LeelapatanaFaculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Teerapat YingchoncharoenFaculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Tachapong NgarmukosFaculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Kulkanya ChokephaibulkitFaculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.ORCID 0000-0002-0140-4600
Suphot SrimahachotaFaculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-5181-961X
Ministry of Public Health · THChulalongkorn University · THMahidol University · THSiriraj Hospital · THBamrasnaradura Infectious Diseases Institute · TH

Funding

Family Health International 360 AEFI surveillance work
6 · The paper itself

Abstract

backgroundMyocarditis and pericarditis cases following Coronavirus 2019 (COVID-19) vaccination were reported worldwide. In Thailand, COVID-19 vaccines were approved for emergency use. Adverse event following immunization (AEFI) surveillance has been strengthened to ensure the safety of the vaccines. This study aimed to describe the characteristics of myocarditis and pericarditis, and identify the factors associated with myocarditis and pericarditis following COVID-19 vaccination in Thailand.

methodWe carried out a descriptive study of reports of myocarditis and pericarditis to Thailand's National AEFI Program (AEFI-DDC) between 1 March and 31 December 2021. An unpaired case-control study was conducted to determine the factors associated with myocarditis and pericarditis after the CoronaVac, ChAdOx1-nCoV, BBIBP-CorV, BNT162b2, and mRNA-1273 vaccines. The cases consisted of COVID-19 vaccine recipients who met the definition of confirmed, probable, or suspected cases of myocarditis or pericarditis within 30 days of vaccination. The controls were people who underwent COVID-19 vaccination between 1 March and 31 December 2021, with no adverse reactions documented after vaccination.

resultsAmong the 31,125 events recorded in the AEFI-DDC after 104.63 million vaccinations, 204 cases of myocarditis and pericarditis were identified. The majority of them were male (69%). The median age was 15 years (interquartile range (IQR): 13-17). The incidence was highest following the BNT162b2 vaccination (0.97 cases per 100,000 doses administered). Ten deaths were reported in this study; no deaths were reported among children who received the mRNA vaccine. Compared with the age-specific incidence of myocarditis and pericarditis in Thailand before the introduction of the COVID-19 vaccination, the incidence of myocarditis and pericarditis after the BNT162b2 vaccine was greater in the 12-17 and 18-20 age groups in both males and females. It was higher after the second dose in 12- to 17-year-olds (2.68 cases per 100,000 doses administered) and highest after the second dose in male 12- to 17-year-olds (4.43 cases per 100,000 doses administered). Young age and a mRNA-based vaccination were associated with myocarditis and pericarditis following administration of the COVID-19 vaccine after multivariate analysis.

conclusionsMyocarditis and pericarditis following vaccination against COVID-19 were uncommon and mild, and were most likely to affect male adolescents. The COVID-19 vaccine offers the recipients enormous benefits. The balance between the risks and advantages of the vaccine and consistent monitoring of AEFI are essential for management of the disease and identification of AEFI.

Indexed as

adverse eventsBNT162b2COVID-19 vaccinesmyocarditispericarditis

Identifiers

PMID37112661
PMCPMC10141407
OpenAlexW4361212986

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.