Evidence map›Paper›PMID 37112993›Full record

ArticleViruses2023

Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease.

Laura C Gunder, Hillary R Johnson, Evan Yao, Tyra H Moyer, Heather A Green, Nathan Sherer, Wei Zhang, Evie H Carchman

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura C GunderDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0000-0002-7619-058X
Hillary R JohnsonDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0000-0001-6748-5143
Evan YaoDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
Tyra H MoyerDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
Heather A GreenCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53705, USA.
Nathan ShererMcArdle Laboratory for Cancer Research and Institute for Molecular Virology, University of Wisconsin, 1111 Highland Avenue, Madison, WI 53706, USA.ORCID 0000-0001-9974-236X
Wei ZhangDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 3170 UW Medical Foundation Centennial Building (MFCB), 1685 Highland Avenue, Madison, WI 53705, USA.ORCID 0000-0003-3154-0256
Evie H CarchmanDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.ORCID 0000-0002-5536-7761
University of Wisconsin–Madison · USUniversity of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin Foundation · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Pamela K Kreeger · 1985 to 2026
$142.6M
UW Surgical Oncology Research Training Program (UW-SORT)T32CA090217 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Muhammed Murtaza, Heather B Neuman · 2001 to 2026
$8.3M
Prevention of anal cancer in People Living with HIV (PLWH)I01BX005608 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI Evie CARCHMAN · 2022 to 2026
–
BLRD VA I01 BX005608NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA090217
6 · The paper itself

Abstract

Anal cancer is a major health problem. This study seeks to determine if the topical protease inhibitor Saquinavir (SQV), is effective at the prevention of anal cancer in transgenic mice with established anal dysplasia.

Indexed as

Anus NeoplasmsOncogene Proteins, ViralPapillomavirus InfectionsAnimalsAntiviral AgentsCarcinogenesisDisease Models, AnimalEnzyme InhibitorsHyperplasiaMiceMice, TransgenicPapillomavirus E7 ProteinsProtease InhibitorsAntiviral AgentsEnzyme InhibitorsOncogene Proteins, ViralPapillomavirus E7 ProteinsProtease Inhibitorsanal canceranal dysplasiachemopreventionHPVsquamous cell carcinoma of the anus

Identifiers

PMID37112993
PMCPMC10146494
OpenAlexW4366588501

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.