Evidence map›Paper›PMID 37113769›Full record

ArticleFrontiers in cell and developmental biology2023

Viviana L Vedder, Tobias Reinberger, Syed M I Haider, Luis Eichelmann, Nadine Odenthal, Salim Abdelilah-Seyfried, Zouhair Aherrahrou, Maximilian Breuer, Jeanette Erdmann

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Viviana L VedderInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Tobias ReinbergerInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Syed M I HaiderInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Luis EichelmannInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Nadine OdenthalInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Salim Abdelilah-SeyfriedFaculty of Mathematics and Natural Sciences, Institute for Biochemistry and Biology, University Potsdam, Potsdam, Germany.
Zouhair AherrahrouInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Maximilian BreuerFaculty of Mathematics and Natural Sciences, Institute for Biochemistry and Biology, University Potsdam, Potsdam, Germany.
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Immungenetics (Germany) · DEGerman Centre for Cardiovascular Research · DEUniversity of Lübeck · DEUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death. Of CVDs, congenital heart diseases are the most common congenital defects, with a prevalence of 1 in 100 live births. Despite the widespread knowledge that prenatal and postnatal drug exposure can lead to congenital abnormalities, the developmental toxicity of many FDA-approved drugs is rarely investigated. Therefore, to improve our understanding of drug side effects, we performed a high-content drug screen of 1,280 compounds using zebrafish as a model for cardiovascular analyses. Zebrafish are a well-established model for CVDs and developmental toxicity. However, flexible open-access tools to quantify cardiac phenotypes are lacking. Here, we provide

Indexed as

cardiovascular diseasedevelopmentdrug effectsdrug screenheartpyHeart4Fishpython GUI applicationZebrafish

Identifiers

PMID37113769
PMCPMC10126419
OpenAlexW4363672453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.