Evidence map›Paper›PMID 37114637›Full record

Trial reportYonsei medical journal2023

Effect of Pharmacist-Led Intervention in Elderly Patients through a Comprehensive Medication Reconciliation: A Randomized Clinical Trial.

Sunmin Lee, Yun Mi Yu, Euna Han, Min Soo Park, Jung-Hwan Lee, Min Jung Chang

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Yonsei medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sunmin LeeDepartment of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Korea.ORCID https://orcid.org/0000-0002-0528-5098
Yun Mi YuDepartment of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Korea.ORCID https://orcid.org/0000-0002-8267-9453
Euna HanDepartment of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Korea.ORCID https://orcid.org/0000-0003-2656-7059
Min Soo ParkDepartment of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Korea.ORCID https://orcid.org/0000-0002-4395-9938
Jung-Hwan LeeDepartment of Hospital Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea. endlesmile@naver.com.ORCID https://orcid.org/0000-0001-7567-0664
Min Jung ChangDepartment of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Korea.ORCID https://orcid.org/0000-0002-8408-5907
Yonsei University · KRInha University Hospital · KR

Funding

Daewoong Pharmaceutical Company DFY2115PNational Research Foundation of Korea NRF-2021R1F1A106009911Yonsei University 2019-22-0082
6 · The paper itself

Abstract

purposePolypharmacy can cause drug-related problems, such as potentially inappropriate medication (PIM) use and medication regimen complexity in the elderly. This study aimed to investigate the feasibility and effectiveness of a collaborative medication review and comprehensive medication reconciliation intervention by a pharmacist and hospitalist for older patients. MATERIALS AND

methodsThis comprehensive medication reconciliation study was designed as a prospective, open-label, randomized clinical trial with patients aged 65 years or older from July to December 2020. Comprehensive medication reconciliation comprised medication reviews based on the PIM criteria. The discharge of medication was simplified to reduce regimen complexity. The primary outcome was the difference in adverse drug events (ADEs) throughout hospitalization and 30 days after discharge. Changes in regimen complexity were evaluated using the Korean version of the medication regimen complexity index (MRCI-K).

resultsOf the 32 patients, 34.4% (n=11/32) reported ADEs before discharge, and 19.2% (n=5/26) ADEs were reported at the 30-day phone call. No ADEs were reported in the intervention group, whereas five events were reported in the control group (

conclusionAs a result, we identified the effect of pharmacist-led interventions using comprehensive medication reconciliation, including the criteria of the PIMs and the MRCI-K, and the differences in ADEs between the intervention and control groups at the 30-day follow-up after discharge in elderly patients.

trial registration(Clinical trial number: KCT0005994).

Indexed as

Drug-Related Side Effects and Adverse ReactionsMedication ReconciliationAgedHospitalizationHumansPatient DischargePharmacistsProspective Studiesadverse drug eventelderlyMedication reconciliationmedication regimen complexitypotentially inappropriate medication

Identifiers

PMID37114637
PMCPMC10151230
OpenAlexW4366956882

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.