Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation P525L (c.1574C > T) in FUS gene.

Masuma Akter, Haochen Cui, Md Abir Hosain, Baojin Ding

Abstract read

In one paragraph

Article in Stem cell research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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1 citing paper in PubMed.

Comparative analysis of chemical and lentiviral approaches in the generation of human induced pluripotent stem cell-derived motor neurons.Neural regeneration research · 2026
Article

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5 · Who and what money

Authors and funding

4 authors.

Masuma AkterDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71130-3932, USA.

Haochen CuiDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71130-3932, USA.

Md Abir HosainDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71130-3932, USA.

Baojin DingDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71130-3932, USA. Electronic address: baojin.ding@lsuhs.edu.

Funding

Determining the Pathogenesis of DYT1 Dystonia in Reprogrammed Human NeuronsR21NS112910 · NINDS · UNIVERSITY OF LOUISIANA AT LAFAYETTE · PI DING, BAOJIN · 2020 to 2020

$399k

NINDS NIH HHS R21 NS112910

6 · The paper itself

Abstract

Mutations in the FUS (fused in sarcoma) gene are implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). However, the pathophysiology underlying these mutations remains elusive. In this study, we created two induced pluripotent stem cell (iPSC) lines through genetic modification of a healthy hiPSC line (WTC11, UCSFi001-A). These iPSC lines carry the heterozygous and homozygous P525L (c.1574C > T) mutation in the FUS gene. We confirmed that both cell lines possess typical stem cell morphology, normal karyotype, and pluripotency. Our iPSC lines offer a valuable resource for investigating the pathological mechanisms underlying the FUS mutation P525L in ALS.

Indexed as

Amyotrophic Lateral SclerosisInduced Pluripotent Stem CellsNeurodegenerative DiseasesHumansMotor NeuronsMutationRNA-Binding Protein FUSFUS protein, humanRNA-Binding Protein FUS

Identifiers

PMID37116345

DOI10.1016/j.scr.2023.103103

PMCPMC10262954

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LicenceCC BY-NC-ND

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