Evidence map›Paper›PMID 37116753›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

Maladaptive lymphangiogenesis is associated with synovial iron accumulation and delayed clearance in factor VIII-deficient mice after induced hemarthrosis.

Esther J Cooke, Bilgimol C Joseph, Chanond A Nasamran, Kathleen M Fisch, Annette von Drygalski

Open access · hybridAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Esther J CookeDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Bilgimol C JosephDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Chanond A NasamranCenter for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, California, USA.
Kathleen M FischCenter for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, California, USA.
Annette von DrygalskiDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA. Electronic address: avondrygalski@health.ucsd.edu.
University of California San Diego · USUC San Diego Health System · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
NCATS NIH HHS UL1 TR001442NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

backgroundMechanisms of iron clearance from hemophilic joints are unknown.

objectivesTo better understand mechanisms of iron clearance following joint bleeding in a mouse model of hemophilia.

methodsHemarthrosis was induced by subpatellar puncture in factor VIII (FVIII)-deficient (FVII

resultsBleed volumes were similar in FVIII

conclusionAccumulation and delayed clearance of iron-laden macrophages were associated with defective lymphangiogenesis after hemarthrosis in FVIII

Indexed as

Hemophilia AHemostaticsAnimalsDisease Models, AnimalFactor VIIIHemarthrosisHumansIronLymphangiogenesisMiceFactor VIIIHemostaticsIronhemarthrosishemophiliainflammationironlymphangiogenesis

Identifiers

PMID37116753
PMCPMC10792547
OpenAlexW4367043586

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.