Evidence map›Paper›PMID 37118804›Full record

ReviewJournal of nanobiotechnology2023

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors.

Siyu Chen, Yuan Su, Manjin Zhang, Yulin Zhang, Peiming Xiu, Wei Luo, Qiuxia Zhang, Xinlu Zhang, Hongbin Liang, Alex Pui-Wai Lee and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Siyu ChenGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yuan SuStomatology Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, 528300, China.
Manjin ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Yulin ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Peiming XiuGuangdong Medical University, Dongguan, 523808, China.
Wei LuoGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qiuxia ZhangGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xinlu ZhangGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hongbin LiangGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Alex Pui-Wai LeePrince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China. shaolongquan@smu.edu.cn.
Jiancheng XiuGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. xiujch@163.com.
Southern Medical University · CNNanfang Hospital · CNChinese University of Hong Kong · CNGuangdong Medical College · CN

Funding

the National Natural Science Foundation of China 81974266
6 · The paper itself

Abstract

Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose, and treat atherosclerosis, but recent studies have also identified that nanomaterials can cause atherosclerosis. Therefore, this review aims to outline the molecular mechanisms and physicochemical properties of nanomaterials that promote atherosclerosis. By analyzing the toxicological effects of nanomaterials on cells involved in the pathogenesis of atherosclerosis such as vascular endothelial cells, vascular smooth muscle cells and immune cells, we aim to provide new perspectives for the prevention and treatment of atherosclerosis, and raise awareness of nanotoxicology to advance the clinical translation and sustainable development of nanomaterials.

Indexed as

AtherosclerosisNanostructuresEndothelial CellsHumansInflammationNanomedicineAtherosclerosisEndothelial cellImmune cellNanomaterialsNanotoxicologySmooth muscle cell

Identifiers

PMID37118804
PMCPMC10148422
OpenAlexW4367319284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.