Evidence map›Paper›PMID 37127362›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.

Amanda M Dossat, Milayna M Kokoska, Jessica R Whitaker-Fornek, Sarah E Sniffen, Aishwarya S Kulkarni, Erica S Levitt, Daniel W Wesson

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amanda M DossatDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Milayna M KokoskaDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Jessica R Whitaker-FornekDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Sarah E SniffenDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Aishwarya S KulkarniDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Erica S LevittDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610.
Daniel W WessonDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 danielwesson@ufl.edu.ORCID 0000-0002-3192-3866
University of Florida · US

Funding

Striatal mechanisms for e-cigarette reinforcement by flavorantsR01DA049545 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DE BIASI, MARIELLA, MA, MINGHONG · 2019 to 2023
$3.2M
Linking Synucleinopathy and Dysfunction of Olfactory PathwaysR01DC016519 · NIDCD · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN, WESSON, DANIEL W · 2017 to 2021
$2.8M
INTER-REGIONAL CODING OF ODOR VALENCE BY NEURAL ENSEMBLESR01DC014443 · NIDCD · UNIVERSITY OF FLORIDA · PI WESSON, DANIEL W · 2015 to 2019
$2.3M
Neural basis of opioid-induced respiratory depressionR01DA047978 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVITT, ERICA SAWYER · 2019 to 2023
$1.8M
Training Program in Chemosensory ScienceT32DC015994 · NIDCD · UNIVERSITY OF FLORIDA · PI Daniel W Wesson · 2018 to 2026
$1.4M
NIDA NIH HHS R01 DA047978NIDA NIH HHS R01 DA049545NIDCD NIH HHS R01 DC014443NIDCD NIH HHS R01 DC016519NIDCD NIH HHS T32 DC015994
6 · The paper itself

Abstract

The gustatory cortex (GC) region of the insular cortex processes taste information in manners important for taste-guided behaviors, including food intake itself. In addition to oral gustatory stimuli, GC activity is also influenced by physiological states including hunger. The specific cell types and molecular mechanisms that provide the GC with such abilities are unclear. Glucagon-like peptide 1 (GLP-1) is produced by neurons in the brain, where it can act on GLP-1 receptor-expressing (GLP-1R+) neurons found in several brain regions. In these brain regions, GLP-1R agonism suppresses homeostatic food intake and dampens the hedonic value of food. Here, we report in mice of both sexes that cells within the GC express

Indexed as

EatingGlucagon-Like Peptide-1 ReceptorAnimalsFemaleGlucagon-Like Peptide 1Insular CortexMaleMiceRatsRats, Sprague-DawleyGlucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptorfeedinggustationingestive behavior

Identifiers

PMID37127362
PMCPMC10254994
OpenAlexW4367596723

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.