Evidence map›Paper›PMID 37129374›Full record

ArticleACS nano2023

Simultaneous Detection of Tumor Derived Exosomal Protein-MicroRNA Pairs with an Exo-PROS Biosensor for Cancer Diagnosis.

Chang-Chieh Hsu, Yunchen Yang, Eric Kannisto, Xie Zeng, Guan Yu, Santosh K Patnaik, Grace K Dy, Mary E Reid, Qiaoqiang Gan, Yun Wu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  3. Exosomes in precision dermatology: From biomarkers to targeted therapeutics in personalized care.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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  17. MicroRNA Gets a Mighty Award.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chang-Chieh HsuDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.
Yunchen YangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0002-4466-8657
Eric KannistoDepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, New York 14263, United States.
Xie ZengDepartment of Electrical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.
Guan YuDepartment of Biostatistics, University at Buffalo, The State University of New York, Buffalo, New York 14263, United States.
Santosh K PatnaikDepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, New York 14263, United States.
Grace K DyDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, New York 14263, United States.
Mary E ReidDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, New York 14263, United States.
Qiaoqiang GanDepartment of Electrical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.
Yun WuDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0002-6926-777X
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
Lung Cancer Early Detection and Immunotherapy Response Prediction and Monitoring with an Exo-PROS Liquid Biopsy AssayR01CA272827 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DY, GRACE, ITO, FUMITO · 2022 to 2025
$3.1M
Noninvasive detection of circulating RNAs for lung cancer early detection and prognosisR33CA191245 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WU, YUN · 2015 to 2018
$1.3M
Exosome-Protein-microRNA-OneStop (Exo-PROS) biosensor: a new liquid biopsy for cancer screening and early detectionR21CA235305 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GAN, QIAOQIANG, WU, YUN · 2019 to 2021
$565k
NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA272827NCI NIH HHS R21 CA235305NCI NIH HHS R33 CA191245
6 · The paper itself

Abstract

Tumor derived exosomes (TEXs) have emerged as promising biomarkers for cancer liquid biopsy. Conventional methods (such as ELISA and qRT-PCR) and emerging biosensing technologies mainly detect a single type of exosomal biomarker due to the distinct properties of different biomolecules. Sensitive detection of two different types of TEX biomarkers, i.e., protein and microRNA combined biomarkers, may greatly improve cancer diagnostic accuracy. We developed an exosome protein microRNA one-stop (Exo-PROS) biosensor that not only selectively captured TEXs but also enabled

Indexed as

Biosensing TechniquesExosomesLung NeoplasmsMicroRNAsBiomarkers, TumorHumansNeoplasm ProteinsBiomarkers, TumorMicroRNAsNeoplasm Proteinsbiosensorcancer liquid biopsyexosomesmicroRNAsproteinssurface plasmon resonance

Identifiers

PMID37129374
PMCPMC10266547
OpenAlexW4367180022

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.