Evidence map›Paper›PMID 37129788›Full record

ArticleEJNMMI research2023

Peptide-based PET imaging agent of tumor TIGIT expression.

Dinghu Weng, Rong Guo, Ziyang Zhu, Yu Gao, Rui An, Xiuman Zhou

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Advancements in non-invasive visualization of the immune checkpoint TIGIT: a systematic review.European journal of nuclear medicine and molecular imaging · 2025
    Pooled it
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Development and characterisation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dinghu Weng *Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China. dinghuweng2013@163.com.ORCID http://orcid.org/0000-0002-0135-5781
Rong Guo *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Ziyang ZhuDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Yu GaoDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Rui AnDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Xiuman ZhouSchool of Pharmaceutical Sciences (Shenzhen), SunYat-Sen University, Shenzhen, 518107, Guangdong, China.
Union Hospital · CNWuhan University · CN

Funding

Wuhan University 2042018kf0179Zhongnan Hospital of Wuhan University PTXM2022029
6 · The paper itself

Abstract

backgroundAccumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a non-invasive method to detect tumor TIGIT expression is crucial to predict the therapeutic effect.

methodsIn this study, a peptide-based PET imaging agent,

resultsThe in vitro studies showed the equilibrium dissociation constant of

conclusion

Indexed as

68GaImmune checkpointImmunotherapyPeptideRadiotracerTIGIT

Identifiers

PMID37129788
PMCPMC10154443
OpenAlexW4367668498

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.