Evidence map›Paper›PMID 37131707›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.

Sathyabaarathi Ravichandran, Fernando Erra-Diaz, Onur E Karakaslar, Radu Marches, Lisa Kenyon-Pesce, Robert Rossi, Damien Chaussabel, Virginia Pascual, Karolina Palucka, Silke Paust and 4 more

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03104075 (Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03104075 phase4completednot on this map

Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines

TypeinterventionalSponsorThe Jackson LaboratoryRan2017 to 2020Enrolled40ConditionsPneumonia, AgingArmsPneumococcal 13valent Conj Vaccine Diphtheria CRM197 Protein, Pneumococcal Vaccine Polyvalent
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Sathyabaarathi RavichandranThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Fernando Erra-DiazThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Onur E KarakaslarThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Radu MarchesThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Lisa Kenyon-PesceUConn Center on Aging, University of Connecticut, Farmington, Connecticut, USA.
Robert RossiThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Damien ChaussabelThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Virginia PascualWeill Cornell Medical College, Department of Pediatrics, NY, USA.
Karolina PaluckaThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Silke PaustDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Moon H NahmDivision of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
George A KuchelUConn Center on Aging, University of Connecticut, Farmington, Connecticut, USA.
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Duygu UcarThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Jackson Laboratory · USUConn Health · USCornell University · USImmunai (United States) · USLeiden University Medical Center · NLScripps Research Institute · USUniversidad de Buenos Aires · ARUniversity of Alabama at Birmingham · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
A deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0M
High-resolution single cell profiling of vaccine responsiveness in the elderlyR01AI142086 · NIAID · JACKSON LABORATORY · PI UCAR, DUYGU · 2019 to 2023
$2.9M
Genomics and Epigenomics of the Elderly Response to Pneumococcal VaccinesR01AG052608 · NIA · JACKSON LABORATORY · PI BANCHEREAU, JACQUES F · 2016 to 2019
$2.5M
NCI NIH HHS P30 CA034196NIAID NIH HHS R01 AI142086NIAID NIH HHS U01 AI165452NIA NIH HHS P30 AG067988NIA NIH HHS R01 AG052608
6 · The paper itself

Abstract

Pneumococcal infections cause serious illness and death among older adults. A capsular polysaccharide vaccine PPSV23 (Pneumovax

Identifiers

PMID37131707
PMCPMC10153339
OpenAlexW4366401419

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.