Evidence map›Paper›PMID 37134160›Full record

ArticleScience advances2023

An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics.

Zhangyuan Pan, Ying Wang, Mingshan Wang, Yuzhe Wang, Xiaoning Zhu, Shenwen Gu, Conghao Zhong, Liqi An, Mingzhu Shan, Joana Damas and 15 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Special Issue "Bioinformatics of Gene Regulations and Structure-2025".International journal of molecular sciences · 2026
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  5. UnlockingNAR genomics and bioinformatics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 5 countries.

Zhangyuan PanDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-5394-3203
Ying WangDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-6920-8692
Mingshan WangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650000, China.ORCID 0000-0003-4663-2735
Yuzhe WangState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-3474-7957
Xiaoning ZhuState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-5743-879X
Shenwen GuDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.
Conghao ZhongNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-0063-4970
Liqi AnDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.
Mingzhu ShanInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Joana DamasThe Genome Center, University of California, Davis, CA 95616, USA.ORCID 0000-0003-4857-2510
Michelle M HalsteadDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0003-0168-2704
Dailu GuanDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-8800-3158
Nares TrakooljulResearch Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.ORCID 0000-0002-3214-2498
Klaus WimmersResearch Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.ORCID 0000-0002-9523-6790
Ye BiDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-7871-5856
Shang WuDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.
Mary E DelanyDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-9901-3597
Xuechen BaiDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0002-7716-5642
Hans H ChengUSDA-ARS, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA.ORCID 0000-0003-2071-4644
Congjiao SunNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing 100193, China.
Ning YangNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-5772-3320
Xiaoxiang HuState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650000, China.ORCID 0000-0001-7045-0283
Harris A LewinThe Genome Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-1043-7287
Lingzhao FangCenter for Quantitative Genetics and Genomics, Aarhus University, Aarhus, 8000, DK.ORCID 0000-0003-1103-3679
Huaijun ZhouDepartment of Animal Science, University of California, Davis, Davis 95616, CA, USA.ORCID 0000-0001-6023-9521
University of California, Davis · USChina Agricultural University · CNMinistry of Agriculture and Rural Affairs · CNChinese Academy of Agricultural Sciences · CNKunming Institute of Zoology · CNResearch Institute for Farm Animal Biology (FBN) · DEAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive characterization of regulatory elements in the chicken genome across tissues will have substantial impacts on both fundamental and applied research. Here, we systematically identified and characterized regulatory elements in the chicken genome by integrating 377 genome-wide sequencing datasets from 23 adult tissues. In total, we annotated 1.57 million regulatory elements, representing 15 distinct chromatin states, and predicted about 1.2 million enhancer-gene pairs and 7662 super-enhancers. This functional annotation of the chicken genome should have wide utility on identifying regulatory elements accounting for gene regulation underlying domestication, selection, and complex trait regulation, which we explored. In short, this comprehensive atlas of regulatory elements provides the scientific community with a valuable resource for chicken genetics and genomics.

Indexed as

ChickensRegulatory Sequences, Nucleic AcidAnimalsChromatinEnhancer Elements, GeneticGenomeGenomicsChromatin

Identifiers

PMID37134160
PMCPMC10156120
OpenAlexW4367856407

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.