ArticleJournal of translational medicine2023
Assessing temporal differences in the predictive power of baseline TyG-related parameters for future diabetes: an analysis using time-dependent receiver operating characteristics.
Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypertriglyceridemia is a dose-dependent risk factor for type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association between the cumulative average triglyceride-glucose-waist circumference index and new-onset hypertension among Chinese middle-aged and older adults-a national prospective study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.Asia Pacific journal of clinical nutrition · 2026Article
- The association between triglyceride glucose-frailty index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between the triglycerideZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Prospective associations of triglyceride-glucose related indices with cardiovascular disease and mortality in individuals with metabolic syndrome: evidence from the UK biobank.Cardiovascular diabetology · 2026Article
- Linear associations of triglyceride-glucose body mass index and atherogenic index of plasma with the risk of diabetes: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- The Triglyceride-Glucose-Chinese Visceral Adiposity Index (TyG-CVAI) outperforms other insulin resistance indices in its association with cardiovascular-kidney-metabolic syndrome severity in type 2 diabetes: a comparative study.Frontiers in nutrition · 2026Article
- Association between triglyceride glucose-body mass index and incident risk of heart failure among patients with type 2 diabetes: a real-world study.Frontiers in endocrinology · 2026Observational
- Multiple machine-learning-driven metabolic frameworks for long-term prognostic risk assessment in patients with coexisting hypertension and obstructive sleep apnea:insights from a multicenter cohort study.Frontiers in physiology · 2026Article
- Comparison of the TyG index, TyG-traditional obesity indices, and TyG-novel obesity indices: does increased complexity help in predicting cardiometabolic multimorbidity?Lipids in health and disease · 2025Article
- Association between the triglyceride glucose-waist-to-height ratio and stroke risk among middle-aged and elderly Chinese adults.BMC endocrine disorders · 2025Article
- Physical performance outweighs grip strength in predicting diabetes risk: evidence from a prospective cohort study.Journal of translational medicine · 2025Article
- High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China.AIDS (London, England) · 2025Article
- Optimal obesity and lipid-related predictors of diabetes mellitus in middle-aged and elderly patients with liver disease in China: a CHARLS cross-sectional study.Diabetology international · 2025Article
- Association between sedentary behavior, physical activity, and the triglyceride glucose index and its derived indices: evidence from NHANES 2013-2018.Journal of exercise science and fitness · 2025Article
- Association of eight anthropometric indexes related to obesity with the prevalence of clinical osteoarthritis among American adults: a national cross-sectional study.European journal of medical research · 2025Article
- Triglyceride-Glucose Index and New-Onset Type 2 Diabetes Mellitus in Middle-Aged Men.Metabolites · 2025Article
- Vitamin E intake mediates the associations of triglyceride-glucose index and its related parameters with phenotypic age acceleration in middle-aged and elderly population.Scientific reports · 2025Article
- Triglyceride glucose-weight-adjusted waist index (TyG-WWI): the best predictor of diabetes mellitus and mortality risks among TyG and TyG-derived indices.BMC endocrine disorders · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist to height ratio (TyG-WHtR)] can predict diabetes; this study aimed to compare the predictive value of the baseline TyG index and TyG-related parameters for the onset of diabetes at different future periods.
methodsWe conducted a longitudinal cohort study involving 15,464 Japanese people who had undergone health physical examinations. The subject's TyG index and TyG-related parameters were measured at the first physical examination, and diabetes was defined according to the American Diabetes Association criteria. Multivariate Cox regression models and time-dependent receiver operating characteristic (ROC) curves were constructed to examine and compare the risk assessment/predictive value of the TyG index and TyG-related parameters for the onset of diabetes in different future periods.
resultsThe mean follow-up period of the current study cohort was 6.13 years, with a maximum of 13 years, and the incidence density of diabetes was 39.88/10,000 person-years. In multivariate Cox regression models with standardized hazard ratios (HRs), we found that both the TyG index and TyG-related parameters were significantly and positively associated with diabetes risk and that the TyG-related parameters were stronger in assessing diabetes risk than the TyG index, with TyG-WC being the best parameter (HR per SD increase: 1.70, 95% CI 1.46, 1.97). In addition, TyG-WC also showed the highest predictive accuracy in time-dependent ROC analysis for diabetes occurring in the short-term (2-6 years), while TyG-WHtR had the highest predictive accuracy and the most stable predictive threshold for predicting the onset of diabetes in the medium- to long-term (6-12 years).
conclusionsThese results suggest that the TyG index combined with BMI, WC, and WHtR can further improve its ability to assess/predict the risk of diabetes in different future periods, where TyG-WC was not only the best parameter for assessing diabetes risk but also the best risk marker for predicting future diabetes in the short-term, while TyG-WHtR may be more suitable for predicting future diabetes in the medium- to long-term.
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