Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage

Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jiang

Open access · goldAbstract read

In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.2field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

[Deubiquitinase USP30 alleviates brain injury after intracerebral hemorrhage by regulating MFN2 ubiquitination].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
Article
Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cuiying PengDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Xiyu GongDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Zhiping HuDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Chunli ChenDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Zheng JiangDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large body of evidence has demonstrated that neuronal apoptosis is involved in the pathological process of secondary brain injury following intracerebral hemorrhage (ICH). Additionally, our previous studies determined that the inhibition of HDAC6 activity by tubacin or specific shRNA can attenuate neuronal apoptosis in an oxygen-glucose deprivation reperfusion model. However, whether the pharmacological inhibition of HDAC6-attenuated neuronal apoptosis in ICH remains unclear. In this study, we used hemin-induced SH-SY5Y cells to simulate a hemorrhage state

Indexed as

Histone Deacetylase 6NeuroblastomaAnimalsApoptosisCerebral HemorrhageHumansHydroxamic AcidsIndolesNeuroprotectionRatsHDAC6 protein, humanHDAC6 protein, ratHistone Deacetylase 6Hydroxamic AcidsIndolestubastatin AAcetylation of α-tubulinApoptosisHDAC6Intracerebral hemorrhageTubastatin A

Identifiers

PMID37138816

DOI10.7717/peerj.15293

PMCPMC10150719

OpenAlexW4367319878

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.