SynthesisFrontiers in neurology2023
Tooth loss and the risk of cognitive decline and dementia: A meta-analysis of cohort studies.
Synthesis in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Association of periodontitis and tooth loss with cognitive decline in the older adults - a systematic review.BMC oral health · 2026Pooled it
- Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data.Journal of oral rehabilitation · 2026Pooled it
- Examining the link between tooth loss and multiple health outcomes: a comprehensive synthesis of evidence from meta-analyses.Frontiers in public health · 2026Pooled it
- Periodontitis and Tooth Loss Are Associated With Higher Risks of Cognitive Disorders: A Systematic Umbrella Meta-Analysis.Clinical and experimental dental research · 2025Pooled it
- Association between periodontal disease and Alzheimer's disease: umbrella review.Frontiers in dental medicine · 2025Pooled it
- Non-Genetic Risk Factors of Alzheimer's Disease: An Updated Umbrella Review.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Moderating Effects of Oral Bacteria and Tooth Loss on Cognitive Performance.JDR clinical and translational research · 2026Article
- From Plant-Derived Compound to Bioactive Agent in Dentistry: The Expanding Role of Thymol.Dentistry journal · 2026Review
- Tooth loss is associated with subsequent brain white matter degradation up to over a decade.Journal of dentistry · 2026Article
- Review
- Discontinuation of dental care and systemic diseases of persons in need of long-term home care - an observational study from the InSEMaP project with German health insurance claims data.BMC geriatrics · 2026Observational
- Cognitive performance in adolescents with perinatally-acquired HIV and associations with oral health in Nigeria.AIDS (London, England) · 2026Article
- Association between dental implants and health outcomes in Korean patients with dementia: a retrospective cohort study.BMC oral health · 2026Article
- Development of an Oral Health Index and Its Association with Oral Health-Related Quality of Life and Cardiovascular Risks: A Cross-Sectional Study.International journal of environmental research and public health · 2026Observational
- Longitudinal association between oral health and dementia among older adults: evidence from the Korean longitudinal study of ageing.BMC geriatrics · 2026Article
- Associations between edentulism and risk of neurodegenerative diseases among middle-aged and older adults in China: a decade-long cohort study.Scientific reports · 2026Article
- Sex differences in the association between tooth loss and socioeconomic status: the 8020 Promotion Foundation Study of Japanese Dental Patients.BMC oral health · 2026Observational
- Association between oral health care behaviors and subjective oral health status among Korean older adults: a national study using community health survey data.Frontiers in public health · 2026Article
- Association between tooth brushing habits and incident disability in community-dwelling older adults: a prospective cohort study.Environmental health and preventive medicine · 2026Article
- An updated systematic review and meta-analysis of tooth loss in patients with periodontitis and the risk of mild cognitive impairment.Frontiers in oral health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Epidemiological studies have shown that tooth loss may be associated with an increased risk of cognitive decline and dementia. However, some results do not show a significant association. Therefore, we performed a meta-analysis to evaluate this association. Methods: Relevant cohort studies were searched in PubMed, Embase, Web of Science (up to May 2022), and the reference lists of retrieved articles. The pooled relative risk ( Results: Eighteen cohort studies met the inclusion criteria. Original studies with 356,297 participants with an average follow-up of 8.6 years (ranging from 2 to 20 years) were included in this study. The pooled Discussion: Tooth loss is associated with a significantly increased risk of cognitive decline and dementia, suggesting that adequate natural teeth are important for cognitive function in older adults. The likely mechanisms mostly suggested include nutrition, inflammation, and neural feedback, especially deficiency of several nutrients like vitamin D.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.