ReviewMolecular psychiatry2023
Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.
Review in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Sex-biased transcriptomic landscapes in bipolar disorder: integrating neurobiology and clinical heterogeneity through cross-study meta-analysis.Biology of sex differences · 2026Pooled it
- Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive function and social cognition in adolescents with bipolar disorder: comparison between manic episode and remission period.European archives of psychiatry and clinical neuroscience · 2026Article
- Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neurostructural Correlates of Polygenic Risk for Coronary Artery Disease in Relation to Youth Bipolar Disorder.Bipolar disorders · 2025Article
- Article
- The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State.Human brain mapping · 2025Article
- Lateral Ventricular Enlargement and Asymmetry and Myelin Content Imbalance in Individuals With Bipolar and Depressive Disorders: Clinical and Research Implications.Bipolar disorders · 2025Article
- Improving the diagnosis of bipolar disorder through machine learning - when is the time right?Neuroscience applied · 2025Article
- The role of blood-brain barrier dysfunction in cognitive impairments in bipolar disorder-a narrative review.Frontiers in human neuroscience · 2025Article
- Cerebrospinal Fluid Biomarkers of Central Nervous System Inflammation Predict Cortical Decline in Bipolar Disorder and Ventricular Enlargement in Healthy Controls.Neuropsychobiology · 2025Article
- Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.BMC psychiatry · 2024Article
- Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review.Brain sciences · 2024Review
- The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders.Scientific reports · 2024Article
- Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach.Frontiers in psychiatry · 2023Article
- Bioinformed idiographic symptom networks to identify neurobiological predictors of affective-state transitions in bipolar disorder.Imaging neuroscience (Cambridge, Mass.)Article
- Understanding the metacognition and impulsivity issues with clinical and cognitive insight in borderline personality disorder - A cross sectional study.Industrial psychiatry journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cross-sectional neuroimaging studies show that bipolar disorder is associated with structural brain abnormalities, predominantly observed in prefrontal and temporal cortex, cingulate gyrus, and subcortical regions. However, longitudinal studies are needed to elucidate whether these abnormalities presage disease onset or are consequences of disease processes, and to identify potential contributing factors. Here, we narratively review and summarize longitudinal structural magnetic resonance imaging studies that relate imaging outcomes to manic episodes. First, we conclude that longitudinal brain imaging studies suggest an association of bipolar disorder with aberrant brain changes, including both deviant decreases and increases in morphometric measures. Second, we conclude that manic episodes have been related to accelerated cortical volume and thickness decreases, with the most consistent findings occurring in prefrontal brain areas. Importantly, evidence also suggests that in contrast to healthy controls, who in general show age-related cortical decline, brain metrics remain stable or increase during euthymic periods in bipolar disorder patients, potentially reflecting structural recovering mechanisms. The findings stress the importance of preventing manic episodes. We further propose a model of prefrontal cortical trajectories in relation to the occurrence of manic episodes. Finally, we discuss potential mechanisms at play, remaining limitations, and future directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.