Evidence map›Paper›PMID 37147394›Full record

Trial reportScientific reports2023

Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia.

Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom, Sailesh Kotecha

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christopher W CourseDepartment of Child Health, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Philip A LewisProteomics Facility, Faculty of Life Sciences, University of Bristol, Bristol, UK.
Sarah J KotechaDepartment of Child Health, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Michael CousinsDepartment of Child Health, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Kylie HartDepartment of Paediatrics, Cardiff and Vale University Health Board, Cardiff, UK.
W John WatkinsDepartment of Child Health, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Kate J HeesomProteomics Facility, Faculty of Life Sciences, University of Bristol, Bristol, UK.
Sailesh KotechaDepartment of Child Health, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK. kotechas@cardiff.ac.uk.
Cardiff University · GBUniversity of Bristol · GBCardiff and Vale University Health Board · GB

Funding

Department of HealthMedical Research Council MR/M022552/1
6 · The paper itself

Abstract

Despite evidence demonstrating persistent lung function deficits in preterm-born children, especially in those who had bronchopulmonary dysplasia (BPD) in infancy, the underlying biological mechanisms explaining these lung function deficits remain poorly understood. We characterised the exhaled breath condensate (EBC) proteome in preterm-born children, with and without BPD; and before and after inhaler treatment. EBC from children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) study, were analysed by Nano-LC Mass Spectrometry with Tandem Mass Tag labelling. Children with percent predicted forced expiratory volume in 1 second ≤ 85% were enrolled to a 12-week blinded randomised trial of inhaled corticosteroids alone (ICS) or with long-acting β

Indexed as

Bronchopulmonary DysplasiaAdrenal Cortex HormonesChildDesmocollinsDesmogleinsDesmosomesgamma CateninHumansInfant, NewbornLungNebulizers and VaporizersProteomicsAdrenal Cortex HormonesDesmocollinsDesmogleinsgamma Catenin

Identifiers

PMID37147394
PMCPMC10163267
OpenAlexW4372337625

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.