Evidence map›Paper›PMID 37147909›Full record

ReviewZoological research2023

Insights into the genetic architecture of congenital heart disease from animal modeling.

Wenjuan Zhu, Cecilia W Lo

Open access · diamondAbstract readReview
In one paragraph

Review in Zoological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Novel compound heterozygous variants in theFrontiers in cardiovascular medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wenjuan ZhuChinese University of Hong Kong, Hong Kong SAR, China.
Cecilia W LoDepartment of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201 USA. E-mail: cel36@pitt.edu.
Chinese University of Hong Kong · CN

Funding

Modeling the complex genetics of congenital heart disease in miceR01HL132024 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2016 to 2019
$3.4M
Mechanism of LV Hypoplasia in Hypoplastic Left Heart Syndrome SupplementR01HL142788 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W., TSANG, MICHAEL WAIKOK · 2018 to 2021
$3.3M
NHLBI NIH HHS R01 HL132024NHLBI NIH HHS R01 HL142788
6 · The paper itself

Abstract

Congenital heart disease (CHD) is observed in up to 1% of live births and is one of the leading causes of mortality from birth defects. While hundreds of genes have been implicated in the genetic etiology of CHD, their role in CHD pathogenesis is still poorly understood. This is largely a reflection of the sporadic nature of CHD, as well as its variable expressivity and incomplete penetrance. We reviewed the monogenic causes and evidence for oligogenic etiology of CHD, as well as the role of

Indexed as

Heart Defects, CongenitalAnimalsHumansMiceCommon copy number variantCongenital heart diseaseDe novo mutationGenetic modifierProtective variantSingle cell sequencing

Identifiers

PMID37147909
PMCPMC10236297
OpenAlexW4372046555

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.