Evidence map›Paper›PMID 37148698›Full record

ArticleJournal of pharmaceutical and biomedical analysis2023

Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma.

Elizabeth Challenger, Sujan Dilly Penchala, Colin Hale, Richard Fitzgerald, Lauren Walker, Helen Reynolds, Justin Chiong, Tom Fletcher, Saye Khoo, Laura Else

Open access · hybridAbstract read
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Degradation of Antiviral Drug Favipiravir Using UV, UV/HLangmuir : the ACS journal of surfaces and colloids · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elizabeth ChallengerDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK. Electronic address: echall@liverpool.ac.uk.
Sujan Dilly PenchalaDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK.
Colin HaleLiverpool University Hospitals NHS Foundation Trust, Prescot Street, Liverpool L7 8XP, UK.
Richard FitzgeraldLiverpool University Hospitals NHS Foundation Trust, Prescot Street, Liverpool L7 8XP, UK.
Lauren WalkerLiverpool University Hospitals NHS Foundation Trust, Prescot Street, Liverpool L7 8XP, UK.
Helen ReynoldsDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK.
Justin ChiongDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK.
Tom FletcherLiverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Saye KhooDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK; Liverpool University Hospitals NHS Foundation Trust, Prescot Street, Liverpool L7 8XP, UK.
Laura ElseDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L7 8TX, UK.
University of Liverpool · GBLiverpool School of Tropical Medicine · GB

Funding

Medical Research Council MR/V028391/1Wellcome Trust 221590
6 · The paper itself

Abstract

Favipiravir (FVP) is a broad-spectrum antiviral that selectively inhibits viral RNA-dependent RNA polymerase, first trialled for the treatment of influenza infection. It has been shown to be effective against a number of RNA virus families including arenaviruses, flaviviruses and enteroviruses. Most recently, FVP has been investigated as a potential therapeutic for severe acute respiratory syndrome coronavirus 2 infection. A liquid chromatography tandem mass spectrometry method for the quantification of FVP in human plasma has been developed and validated for use in clinical trials investigating favipiravir as treatment for coronavirus disease-2019. Samples were extracted by protein precipitation using acetonitrile, using

Indexed as

COVID-19Tandem Mass SpectrometryAmidesChromatography, High Pressure LiquidChromatography, LiquidFormatesHumansPyrazinesReproducibility of ResultsAmidesfavipiravirFormatesformic acidPyrazinesBioanalysisCOVID-19FavipiravirPharmacokineticsSARS-CoV-2

Identifiers

PMID37148698
PMCPMC7617888
OpenAlexW4367692544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.