Evidence map›Paper›PMID 37150783›Full record

Trial reportClinical research in cardiology : official journal of the German Cardiac Society2023

Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization.

Rutao Wang, Mattia Lunardi, Hironori Hara, Chao Gao, Masafumi Ono, Piroze M Davierwala, David R Holmes, Friedrich W Mohr, Nick Curzen, Francesco Burzotta and 9 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00114972 phase3unknown statusnot on this map

SYNTAX Study: SYNergy Between PCI With TAXUS and Cardiac Surgery

TypeinterventionalSponsorBoston Scientific CorporationRan2005 to 2012Enrolled1,800ConditionsCoronary Artery DiseaseArmsPolymer-based Paclitaxel-Eluting TAXUS Express2-SR Stent, Coronary Artery Bypass Surgery
NCT03417050 completednot on this map

Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival

TypeobservationalSponsorErasmus Medical CenterRan2016 to 2019Enrolled2,636ConditionsCoronary Artery DiseaseArmsNo intervention will take place for this retrospective and observational study.
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Etiology of Coronary Reintervention After Coronary Artery Bypass Surgery.Journal of cardiovascular development and disease · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 8 countries.

Rutao Wang *Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Mattia Lunardi *The Smart Sensors Laboratory at the Lambe Institute for Translational Medicine and CURAM, University of Galway, Galway, Ireland.
Hironori HaraDepartment of Cardiology, CORRIB Research Center for Advanced Imaging and Core Laboratory, National University of Ireland, Galway (NUIG), University Road, Galway, H91 TK33, Ireland.
Chao GaoDepartment of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Masafumi OnoDepartment of Cardiology, CORRIB Research Center for Advanced Imaging and Core Laboratory, National University of Ireland, Galway (NUIG), University Road, Galway, H91 TK33, Ireland.
Piroze M DavierwalaDivision of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Canada.
David R HolmesMayo Clinic, Rochester, MN, USA.
Friedrich W MohrDepartment of Cardiac Surgery, Heart Centre Leipzig, Leipzig, Germany.
Nick CurzenFaculty of Medicine, University of Southampton and Cardiology Department, University Hospital Southampton, Southampton, UK.
Francesco BurzottaFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Robert-Jan van GeunsDepartment of Cardiology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Arie Pieter KappeteinDepartment of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Stuart J HeadDepartment of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Daniel J F M ThuijsDepartment of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Ling TaoDepartment of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Scot GargEast Lancashire Hospitals NHS Trust, Blackburn, Lancashire, UK.
Yoshinobu OnumaDepartment of Cardiology, CORRIB Research Center for Advanced Imaging and Core Laboratory, National University of Ireland, Galway (NUIG), University Road, Galway, H91 TK33, Ireland.
William WijnsThe Smart Sensors Laboratory at the Lambe Institute for Translational Medicine and CURAM, University of Galway, Galway, Ireland.
Patrick W SerruysDepartment of Cardiology, CORRIB Research Center for Advanced Imaging and Core Laboratory, National University of Ireland, Galway (NUIG), University Road, Galway, H91 TK33, Ireland. patrick.w.j.c.serruys@gmail.com.ORCID http://orcid.org/0000-0002-9636-1104
Erasmus University Rotterdam · NLOllscoil na Gaillimhe – University of Galway · IERadboud University Nijmegen · NLEast Lancashire Hospitals NHS Trust · GBLeipzig Heart Institute · DEMayo Clinic in Arizona · USNational University of Ireland · IEUniversità Cattolica del Sacro Cuore · ITUniversity Health Network · CAUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Verona · ITXijing Hospital · CN

Funding

Science Foundation Ireland Research Professorship Grant 15/RP/2765
6 · The paper itself

Abstract

backgroundThe SYNTAX trial demonstrated negative impact of repeat revascularization (RR) on 5-year outcomes following PCI/CABG in patients with three-vessel(3VD) and/or left main coronary artery disease(LMCAD). We aimed to investigate the impact of RR within 5 years, on 10-year mortality in patients with 3VD and/or LMCAD after PCI/CABG.

methodsThe SYNTAXES study evaluated the vital status out to 10 years of patients with 3VD and/or LMCAD. Patients were stratified by RR within 5 years and randomized treatment. The association between RR within 5 years and 10-year mortality was assessed.

resultsA total of 330 out of 1800 patients (18.3%) underwent RR within 5 years. RR occurred more frequently after initial PCI than after initial CABG (25.9% vs. 13.7%, p < 0.001). Overall, 10-year mortality was comparable between patients undergoing RR and those not (28.2% vs. 26.1%, adjusted HR: 1.17, 95%CI 0.93-1.48, p = 0.187). In the PCI arm, RR was associated with a trend toward higher 10-year mortality (adjusted HR: 1.29, 95%CI 0.97-1.72, p = 0.075), while in the CABG arm, the trend was opposite (adjusted HR: 0.74, 95%CI 0.46-1.20, p = 0.219). Among patients requiring RR, those who underwent PCI as initial revascularization had a higher risk of 10-year mortality compared to initial CABG (33.5% vs. 17.6%, adjusted HR: 2.09, 95%CI 1.21-3.61, p = 0.008).

conclusionIn the SYNTAXES study, RR within 5 years had no impact on 10-year all-cause death in the population overall. Among patients requiring any repeat procedures, 10-year mortality was higher after initial treatment with PCI than after CABG. These exploratory findings should be investigated with larger populations in future studies.

trial registrationURL: https://www. CLINICALTRIALS: gov ; SYNTAXES Unique identifier: NCT03417050. URL: https://www. CLINICALTRIALS: gov ; SYNTAX Unique identifier: NCT00114972.

Indexed as

Coronary Artery DiseasePercutaneous Coronary InterventionCoronary Artery BypassHumansTreatment OutcomeAll-cause deathCoronary artery bypass graftingPercutaneous coronary interventionRepeat revascularizationSYNTAX

Identifiers

PMID37150783
PMCPMC10449944
OpenAlexW4375856580

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.