Evidence map›Paper›PMID 37152117›Full record

ReviewImmunometabolism (Cobham, Surrey)2023

Dietary cholesterol in alcohol-associated liver disease.

Lin Jia

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunometabolism (Cobham, Surrey), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lin JiaDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.
The University of Texas at Dallas · US

Funding

Role of Hepatocyte TLR4 in Alcohol-induced Steatohepatitis and Insulin ResistanceK01AA024809 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI JIA, LIN · 2017 to 2020
$598k
Role of Dietary Cholesterol in Alcoholic Steatohepatitis and Insulin ResistanceR03AA028585 · NIAAA · UNIVERSITY OF TEXAS DALLAS · PI JIA, LIN · 2021 to 2022
$155k
NIAAA NIH HHS K01 AA024809NIAAA NIH HHS R03 AA028585
6 · The paper itself

Abstract

There is an increasing prevalence of alcohol-associated liver disease (ALD) worldwide. In addition to excessive alcohol consumption, other nutritional factors have been shown to affect the initiation and progression of ALD. The emerging role of cholesterol in exacerbating ALD has been reported recently and the underlying mechanisms are discussed. In addition, the interplay between dietary cholesterol and alcohol on cholesterol metabolism is reviewed. Furthermore, we highlight the therapeutic potential of cholesterol-lowering drugs in managing the onset and severity of ALD. Finally, we suggest the future mechanistic investigation of the effect of cholesterol on insulin resistance and intestinal inflammation in the exacerbation of alcohol-induced cellular and systemic dysfunction.

Indexed as

alcoholalcohol-associated liver diseasecholesterolcholesterol-lowering pharmacotherapies

Identifiers

PMID37152117
PMCPMC10158609
OpenAlexW4368618136

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.