ArticleFrontiers in cardiovascular medicine2023
Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Analyzing the role of ATP-dependent potassium channels in the regulation of coronary metabolic vasodilation during exercise.Basic research in cardiology · 2026Review
- Cardiac rehabilitation in porcine models: Advances in therapeutic strategies for ischemic heart disease.Zoological research · 2025Review
- Empagliflozin in Acute Myocardial Infarction Reduces No-Reflow and Preserves Cardiac Function by Preventing Endothelial Damage.JACC. Basic to translational science · 2025Article
- Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion.Basic research in cardiology · 2024Article
- No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs.Basic research in cardiology · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Diazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretreatment in juvenile pigs with coronary occlusion/reperfusion. We aimed to study the use of diazoxide in a more realistic adult pig model of reperfused acute myocardial infarction when diazoxide was administered just before reperfusion. Methods and results: In a first approach, we pretreated anaesthetised adult Göttingen minipigs with 7 mg kg Conclusions: Cardioprotection by diazoxide pretreatment was confirmed in adult pigs with reperfused acute myocardial infarction but is not feasible when diazoxide is administered in a more realistic scenario before reperfusion and causes hypotension.
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