Evidence map›Paper›PMID 37154177›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?

Anisa J Marshall, Aimee Gaubert, Arunima Kapoor, Alick Tan, Elissa McIntosh, Jung Yun Jang, Belinda Yew, Jean K Ho, Anna E Blanken, Shubir Dutt and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Endothelial progenitor cells and cerebral small vessel disease inCerebral circulation - cognition and behavior · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Anisa J MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Aimee GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Alick TanDepartment of Clinical Pharmacy, University of Southern California, Los Angeles, CA, USA.
Elissa McIntoshDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Belinda YewDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Anna E BlankenDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Kathleen RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Daniel A NationInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USUniversity of Southern California · USIcahn School of Medicine at Mount Sinai · USUniversity of Arizona · US

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

backgroundDepletion of blood-derived progenitor cells, including so called "early endothelial progenitor cells", has been observed in individuals with early stage Alzheimer's disease relative to matched older control subjects. These findings could implicate the loss of angiogenic support from hematopoietic progenitors or endothelial progenitors in cognitive dysfunction.

objectiveTo investigate links between progenitor cell proliferation and mild levels of cognitive dysfunction.

methodsWe conducted in vitro studies of blood-derived progenitor cells using blood samples from sixty-five older adults who were free of stroke or dementia. Peripheral blood mononuclear cells from venous blood samples were cultured in CFU-Hill media and the number of colony forming units were counted after 5 days in vitro. Neuropsychological testing was administered to all participants.

resultsFewer colony forming units were observed in samples from older adults with a Clinical Dementia Rating global score of 0.5 versus 0. Older adults whose samples developed fewer colony forming units exhibited worse performance on neuropsychological measures of memory, executive functioning, and language ability.

conclusionThese data suggest blood progenitors may represent a vascular resilience marker related to cognitive dysfunction in older adults.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedCognitionHumansLeukocytes, MononuclearNeuropsychological TestsStem CellsAlzheimer’s diseasecognitive dysfunctionprogenitor cellsvascular resilience

Identifiers

PMID37154177
PMCPMC10258882
OpenAlexW4372272107

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.