ArticleProceedings of the National Academy of Sciences of the United States of America2023
Croquemort elicits activation of the immune deficiency pathway in ticks.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- A lipid-binding protein in black-legged tick saliva selectively recognizesbioRxiv : the preprint server for biology · 2026Article
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- Comparative analysis of defensin expression inFrontiers in veterinary science · 2026Article
- ATF6 enables pathogen infection in ticks by inducingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors.Nature communications · 2025Article
- Immune-Related Genes in the Honey Bee MiteInsects · 2025Article
- Vectorial dynamics underpinning current and future tick-borne virus emergence in Europe.The Journal of general virology · 2024Review
- Genetic manipulation of anmBio · 2024Article
- Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness.Nature communications · 2024Article
- Severe fever with thrombocytopenia syndrome virus infection shapes gut microbiome of the tick vector Haemaphysalis longicornis.Parasites & vectors · 2024Article
- Identification and characterization of a Relish-type NF-κB, DvRelish, inFrontiers in cellular and infection microbiology · 2024Article
- Anti-tick vaccine candidate subolesin is important for blood feeding and innate immune gene expression in soft ticks.PLoS neglected tropical diseases · 2023Article
- Article
- Tick extracellular vesicles in host skin immunity and pathogen transmission.Trends in parasitology · 2023Review
- Cholesterol Contributes to Risk, Severity, and Machine Learning-Driven Diagnosis of Lyme Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- PERK-mediated antioxidant response is key for pathogen persistence in ticks.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Anya J O'NealDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Nisha SinghDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Agustin RolandelliDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0003-1059-3578
Hanna J LaukaitisDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-2267-4634
Xiaowei WangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Dana K ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-5212-2494
Brianna D YoungDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-7742-8860
Sukanya NarasimhanDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510.
Shraboni DuttaDepartment of Veterinary Medicine, University of Maryland, College Park, MD 20742.ORCID 0000-0002-8000-8111
Greg A SnyderInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201.
Sourabh SamaddarDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0003-0746-3924
Liron MarninDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
L Rainer ButlerDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
M Tays MendesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-9508-9372
Francy E Cabrera PazDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Luisa M ValenciaDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Eric J SundbergDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0003-0478-3033
Erol FikrigDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-5884-6047
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, MD 20742.ORCID 0000-0002-7504-4628
David J WeberDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-8824-1110
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0001-8740-2667
University of Maryland, Baltimore · USUniversity of Maryland, College Park · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Jonathan D Oliver · 2018 to 2026
$13.5MDevelopment of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9MUbiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2MBORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2MTick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1MBBA57-Mediated Borrelial Persistence, Genesis of Inflammation and ImmunityR01AI116620 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2015 to 2019
$1.9MHost Response in S. aureus Infections: Role of T cellsR01AI052397 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI TZIANABOS, ARTHUR O · 2002 to 2006
$1.8MSignal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3MTICK-PATHOGEN INTERFACE: INVESTIGATING CROSSTALK BETWEEN STRESS RESPONSES AND IMMUNITYR21AI139772 · NIAID · WASHINGTON STATE UNIVERSITY · PI SHAW, DANA KATHLEEN · 2018 to 2019
$421kFunctional Impact of Stress Granules on Tick-Microbe InteractionsR21AI148578 · NIAID · WASHINGTON STATE UNIVERSITY · PI SHAW, DANA KATHLEEN · 2020 to 2021
$421kCharacterization of a Lipid Receptor in Tick Humoral ImmunityF31AI152215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI O’NEAL, ANYA JOSEPHINE · 2020 to 2021
$81kNCATS NIH HHS UL1 TR001863NIAID NIH HHS F31 AI152215NIAID NIH HHS F31 AI167471NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI052397NIAID NIH HHS R01 AI080615NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI116620NIAID NIH HHS R01 AI134696NIAID NIH HHS R21 AI139772NIAID NIH HHS R21 AI148578NIGMS NIH HHS R01 GM129327
Abstract
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an
Indexed as
ArthropodsBacterial InfectionsBorrelia burgdorferiIxodesLyme DiseaseAnimalsNF-kappa BNF-kappa Barthropod immunologyentomologyticks
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.