Evidence map›Paper›PMID 37157910›Full record

ArticleBiological reviews of the Cambridge Philosophical Society2023

Reuniting philosophy and science to advance cancer research.

Thomas Pradeu, Bertrand Daignan-Fornier, Andrew Ewald, Pierre-Luc Germain, Samir Okasha, Anya Plutynski, Sébastien Benzekry, Marta Bertolaso, Mina Bissell, Joel S Brown and 28 more

Open access · hybridAbstract read
In one paragraph

Article in Biological reviews of the Cambridge Philosophical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  3. Top-Down Coercive Mechanisms and the Major Transitions in Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Review
  5. Cancer research and the mainstream of biology.Frontiers in cell and developmental biology · 2025
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 11 countries.

Thomas PradeuCNRS UMR5164 ImmunoConcEpT, University of Bordeaux, 146 rue Leo Saignat, Bordeaux, 33076, France.ORCID 0000-0002-6590-3281
Bertrand Daignan-Fornier *CNRS UMR 5095 Institut de Biochimie et Génétique Cellulaires, University of Bordeaux, 1 rue Camille St Saens, Bordeaux, 33077, France.
Andrew Ewald *Departments of Cell Biology and Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Pierre-Luc Germain *Department of Health Sciences and Technology, Institute for Neurosciences, Eidgenössische Technische Hochschule (ETH) Zürich, Universitätstrasse 2, Zürich, 8092, Switzerland.
Samir Okasha *Department of Philosophy, University of Bristol, Cotham House, Bristol, BS6 6JL, UK.
Anya Plutynski *Department of Philosophy, Washington University in St. Louis, and Associate with Division of Biology and Biomedical Sciences, St. Louis, MO, 63105, USA.
Sébastien Benzekry *Computational Pharmacology and Clinical Oncology (COMPO) Unit, Inria Sophia Antipolis-Méditerranée, Cancer Research Center of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University UM105, 27, bd Jean Moulin, Marseille, 13005, France.
Marta Bertolaso *Research Unit of Philosophy of Science and Human Development, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21-00128, Rome, Italy.
Mina Bissell *Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA.
Joel S Brown *Department of Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Benjamin Chin-Yee *Division of Hematology, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, 800 Commissioners Rd E, London, ON, Canada.
Ian Chin-Yee *Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, 800 Commissioners Rd E, London, ON, Canada.
Hans Clevers *Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland.
Laurent Cognet *CNRS UMR 5298, Laboratoire Photonique Numérique et Nanosciences, University of Bordeaux, Rue François Mitterrand, Talence, 33400, France.
Marie Darrason *Department of Pneumology and Thoracic Oncology, University Hospital of Lyon, 165 Chem. du Grand Revoyet, 69310 Pierre Bénite, Lyon, France.
Emmanuel Farge *Mechanics and Genetics of Embryonic and Tumor Development group, Institut Curie, CNRS, UMR168, Inserm, Centre Origines et conditions d'apparition de la vie (OCAV) Paris Sciences Lettres Research University, Sorbonne University, Institut Curie, 11 rue Pierre et Marie Curie, Paris, 75005, France.
Jean Feunteun *INSERM U981, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, 94800, France.ORCID 0000-0003-1212-9189
Jérôme Galon *INSERM UMRS1138, Integrative Cancer Immunology, Cordelier Research Center, Sorbonne Université, Université Paris Cité, 15 rue de l'École de Médecine, Paris, 75006, France.
Elodie Giroux *Lyon Institute of Philosophical Research, Lyon 3 Jean Moulin University, 1 Av. des Frères Lumière, Lyon, 69007, France.
Sara Green *Section for History and Philosophy of Science, Department of Science Education, University of Copenhagen, Rådmandsgade 64, Copenhagen, 2200, Denmark.
Fridolin Gross *CNRS UMR5164 ImmunoConcEpT, University of Bordeaux, 146 rue Leo Saignat, Bordeaux, 33076, France.
Fanny Jaulin *INSERM U1279, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, 94800, France.
Rob Knight *Department of Bioengineering, University of California San Diego, 3223 Voigt Dr, La Jolla, CA, 92093, USA.
Ezio Laconi *Department of Biomedical Sciences, School of Medicine, University of Cagliari, Via Università 40, Cagliari, 09124, Italy.
Nicolas Larmonier *CNRS UMR5164 ImmunoConcEpT, University of Bordeaux, 146 rue Leo Saignat, Bordeaux, 33076, France.
Carlo Maley *Arizona Cancer Evolution Center, Arizona State University, 427 East Tyler Mall, Tempe, AZ, 85287, USA.
Alberto Mantovani *Department of Biomedical Sciences, Humanitas University, 4 Via Rita Levi Montalcini, 20090 Pieve Emanuele, Milan, Italy.
Violaine Moreau *INSERM UMR1312, Bordeaux Institute of Oncology (BRIC), University of Bordeaux, 146 Rue Léo Saignat, Bordeaux, 33076, France.
Pierre Nassoy *CNRS UMR 5298, Laboratoire Photonique Numérique et Nanosciences, University of Bordeaux, Rue François Mitterrand, Talence, 33400, France.
Elena Rondeau *INSERM U1111, ENS Lyon and Centre International de Recherche en Infectionlogie (CIRI), 46 Allée d'Italie, Lyon, 69007, France.
David Santamaria *Molecular Mechanisms of Cancer Program, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Salamanca, 37007, Spain.
Catherine M Sawai *INSERM UMR1312, Bordeaux Institute of Oncology (BRIC), University of Bordeaux, 146 Rue Léo Saignat, Bordeaux, 33076, France.
Andrei Seluanov *Department of Biology and Medicine, University of Rochester, Rochester, NY, 14627, USA.
Gregory D Sepich-Poore *Micronoma, 6342 Ferris Square, San Diego, CA, 92121, USA.
Vanja Sisirak *CNRS UMR5164 ImmunoConcEpT, University of Bordeaux, 146 rue Leo Saignat, Bordeaux, 33076, France.
Eric Solary *INSERM U1287, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, 94800, France.
Sarah Yvonnet *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, Copenhagen, DK-2200, Denmark.
Lucie LaplaneCNRS UMR8590, Institut d'Histoire et Philosophie des Sciences et des Technique, University Paris I Panthéon-Sorbonne, 13 rue du Four, Paris, 75006, France.ORCID 0000-0003-0185-3323
Centre National de la Recherche Scientifique · FRInserm · FRUniversité Claude Bernard Lyon 1 · FREquilibrium Research · GBUniversité de Bordeaux · FRUniversity of Copenhagen · DKWestern University · CAConsejo Superior de Investigaciones Científicas · ESHumanitas University · ITJohns Hopkins University · USLawrence Berkeley National Laboratory · USMicron (United States) · USMoffitt Cancer Center · USRoche (Switzerland) · CHUniversità Campus Bio-Medico · ITUniversity of Bristol · GBUniversity of Cagliari · ITUniversity of California San Diego · USUniversity of Zurich · CHWashington University in St. Louis · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9M
Molecular, Cellular and Tissue Characterization UnitU2CCA233254 · NCI · DUKE UNIVERSITY · PI HWANG, E.SHELLEY · 2018 to 2023
$11.4M
The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO, SHIBATA, DARRYL K · 2018 to 2022
$8.6M
Modeling Neoplastic Progression in Barrett's Esophagus - Renewal -2R01CA140657 · NCI · WISTAR INSTITUTE · PI Carlo Maley · 2009 to 2026
$5.0M
Regulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7M
A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineageR21CA257980 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MALEY, CARLO, WEISS, RON · 2022 to 2023
$576k
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA140657NCI NIH HHS R21 CA257980NCI NIH HHS U2C CA233254NCI NIH HHS U54 CA217376NIA NIH HHS P01 AG047200NIA NIH HHS R37 AG046320
6 · The paper itself

Abstract

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

Indexed as

NeoplasmsPhilosophyInterdisciplinary StudiesResearchcancer stem cellsclonal evolutiondriver mutationmulticellularityoncoimmunologyphilosophy of cancertumorigenesistumour microenvironment

Identifiers

PMID37157910
PMCPMC10869205
OpenAlexW4375954596

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.