ArticleeLife2023
Endosomal trafficking of two-pore K
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- Structural evidence that a lipid plug controls KNature communications · 2026Article
- KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular mechanisms of NLRP3 inflammasome activation.Experimental & molecular medicine · 2026Review
- Insights into the structure and modulation of human TWIK-2.Nature communications · 2026Article
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- The Extracellular Matrix and the Immune System in Acute Lung Injury: Partners in Damage and Repair.Biomedicines · 2025Review
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- Acute lung injury: pathogenesis and treatment.Journal of translational medicine · 2025Review
- Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/p-Tau pathway.Acta pharmacologica Sinica · 2025Article
- Structure of the human KNature structural & molecular biology · 2025Article
- ACPA-Induced ATP release and KCell communication and signaling : CCS · 2025Article
- Tolerance to Lung Infection in TWIK2 KbioRxiv : the preprint server for biology · 2025Article
- Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Endosomal traffic disorders: a driving force behind neurodegenerative diseases.Translational neurodegeneration · 2024Review
- Prenatal Stress and Ethanol Exposure: Microbiota-Induced Immune Dysregulation and Psychiatric Risks.International journal of molecular sciences · 2024Review
- ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation.Journal of translational medicine · 2024Article
- Detecting organelle-specific activity of potassium channels with a DNA nanodevice.Nature biotechnology · 2024Article
- The ion channels of endomembranes.Physiological reviews · 2024Review
- Extracellular histones promote TWIK2-dependent potassium efflux and associated NLRP3 activation in alveolar macrophages during sepsis-induced lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Long Shuang HuangDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.
Mohammad AnasDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.
Jingsong XuDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.
Bisheng ZhouDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.
Peter T TothFluorescence Imaging Core, The University of Illinois College of Medicine, Chicago, United States.
Yamuna KrishnanDepartment of Chemistry, University of Chicago, Chicago, United States.ORCID 0000-0001-5282-8852
Anke DiDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.ORCID 0000-0001-5055-1407
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, United States.ORCID 0000-0002-8205-7128
Illinois College · USFluor (United States) · US
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MTrpm2 Regulation of Phagocyte Bactericidal Activity and Resolution of Lung InjuryP01HL077806 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHAO, YOU-YANG · 2005 to 2019
$27.0MTRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6MSynthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2021 to 2025
$11.8MMesenchymal-Endothelial Transition as a Homeostatic Regenerative Mechanism in Acute Lung InjuryR01HL090152 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B., REHMAN, JALEES · 2007 to 2019
$5.9MEndothelial Regeneration Following Lung Vascular InjuryR01HL118068 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B., REHMAN, JALEES · 2014 to 2017
$2.4MCalcium homeostasis in organellesR01NS112139 · NINDS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2020 to 2024
$1.8MNHLBI NIH HHS P01 HL060678NHLBI NIH HHS P01 HL077806NHLBI NIH HHS P01 HL151327NHLBI NIH HHS R01 HL090152NHLBI NIH HHS R01 HL118068NHLBI NIH HHS T32 HL007829NINDS NIH HHS R01 NS112139
Abstract
Potassium efflux via the two-pore K
Indexed as
InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAdenosine TriphosphateAnimalsBiological TransportCaspase 1Interleukin-1betaMacrophagesMicePotassium Channels, Tandem Pore DomainAdenosine TriphosphateCaspase 1InflammasomesInterleukin-1betaKcnk6 protein, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePotassium Channels, Tandem Pore DomainATPcalciumcaspase 1cell biologyexocytosismouseP2X7Rab11a
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.