ArticleImmunity2023
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Cell surface ADGRG1 and CD86 expression identifies antitumor CD4Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lenalidomide boosts CD1d-Vδ2 bispecific antibody-engaged Vγ9Vδ2-T cell effector functions via CD28, Notch signaling and IL-2 release.Journal for immunotherapy of cancer · 2026Article
- Endogenous CD28 Drives the Persistent Activity of CAR T Cells in Myeloma and Lymphoma Models.Blood cancer discovery · 2026Article
- Plasma membrane invaginations and their diverse cellular functions.BMC biology · 2026Review
- Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia.Journal of translational medicine · 2026Article
- Exercise and CD8Journal of molecular medicine (Berlin, Germany) · 2026Review
- The emerging role of aptamers in targeted cancer immunotherapy.Molecular therapy. Oncology · 2026Review
- Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose-mesenchymal transformation.Nature cell biology · 2026Article
- Article
- isMap - immunological synapse map analysis program.Frontiers in immunology · 2026Article
- On the same side: VISTA and its ligands interact in cis on the cell surface.Protein science : a publication of the Protein Society · 2026Article
- CD28 and ICOS in immune regulation: Structural insights and therapeutic targeting.Bioorganic & medicinal chemistry letters · 2025Review
- Hub genes and key pathways of Graves' disease: bioinformatics analysis and validation.Hormones (Athens, Greece) · 2025Article
- Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.Signal transduction and targeted therapy · 2025Review
- A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo.The Journal of experimental medicine · 2025Article
- EphA2 and Ephrin-A1 Utilize the Same Interface for BothbioRxiv : the preprint server for biology · 2025Article
- Activated platelets stimulate effector CD8+ T cells to enhance HNSCC immunotherapy efficacy.Discover oncology · 2025Article
- OX40-OX40L Axis in Cutaneous T-Cell Lymphomas: Pathogenic, Prognostic, and Potential Therapeutic Perspectives.Biomolecules · 2025Review
- Immune cell phenotypes as causal factors in liver disease progression revealed by Mendelian randomization.Scientific reports · 2025Article
- Intranodal injection of neoantigen-bearing engineeredActa pharmaceutica Sinica. B · 2025Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 2 institutions in 1 country.
Yunlong ZhaoDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: yuz798@ucsd.edu.
Christine CaronDepartment of Pathology, University of California San Diego, La Jolla, CA 92093, USA.
Ya-Yuan ChanDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Calvin K LeeDepartment of Pathology, University of California San Diego, La Jolla, CA 92093, USA.
Xiaozheng XuDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Jibin ZhangDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Takeya MasubuchiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Chuan WuExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Jack D BuiDepartment of Pathology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: jbui@ucsd.edu.
Enfu HuiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: enfuhui@ucsd.edu.
University of California San Diego · USNational Cancer Institute · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0McGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MRegulation of PD-L1/PD-1 immune checkpoints by cis-interactionsR37CA239072 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUI, ENFU · 2019 to 2025
$2.5MJEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579kCis-interaction mediated CD28 costimulationK99AI159295 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHAO, YUNLONG · 2022 to 2023
$246kNCI NIH HHS P30 CA023100NCI NIH HHS R37 CA239072NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS K99 AI159295NIDA NIH HHS 75N95020D00005NIH HHS S10 OD023527NINDS NIH HHS P30 NS047101ORFDO NIH HHS 75N99020D00005
Abstract
B7 ligands (CD80 and CD86), expressed by professional antigen-presenting cells (APCs), activate the main co-stimulatory receptor CD28 on T cells in trans. However, in peripheral tissues, APCs expressing B7 ligands are relatively scarce. This raises the questions of whether and how CD28 co-stimulation occurs in peripheral tissues. Here, we report that CD8
Indexed as
CD28 AntigensCD8-Positive T-LymphocytesAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenCell Adhesion MoleculesLigandsLymphocyte ActivationMembrane GlycoproteinsMiceSynaptic MembranesAntigens, CDB7-1 AntigenB7-2 AntigenCD28 AntigensCell Adhesion MoleculesLigandsMembrane Glycoproteinsanti-tumor immunityB7CD28cis-interactionsendocytosismembrane curvaturesPI3KPKCθSNX9T cell
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.