Evidence map›Paper›PMID 37160571›Full record

SynthesisJournal of cancer survivorship : research and practice2024

Moderators of exercise effects on self-reported cognitive functioning in cancer survivors: an individual participant data meta-analysis.

Anouk E Hiensch, Julia Beckhaus, Lenja Witlox, Evelyn M Monninkhof, Sanne B Schagen, Jonna K van Vulpen, Maike G Sweegers, Robert U Newton, Neil K Aaronson, Daniel A Galvão and 21 more

Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cancer survivorship : research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 19 institutions in 8 countries.

Anouk E HienschJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Julia BeckhausJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Lenja WitloxJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Evelyn M MonninkhofJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sanne B SchagenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jonna K van VulpenDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maike G SweegersDivision of Psychosocial Research and Epidemiology & Center for Quality of Life, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Neil K AaronsonDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
Martijn M StuiverDivision of Psychosocial Research and Epidemiology & Center for Quality of Life, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Ilse MestersDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands.
Hans KnoopDepartment of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Martine M GoedendorpDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Martin BohusInstitute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Mannheim, Heidelberg University, Heidelberg, Germany.
Lene ThorsenNational Advisory Unit on Late Effects after Cancer, Department of Oncology, Oslo University Hospital, Oslo, Norway.
Karl-Heinz SchulzAthleticum - Competence Center for Sports- and Exercise Medicine and Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martina E SchmidtDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, USA.
Gabe S SonkeNetherlands Cancer Institute, Amsterdam, The Netherlands.
Wim H van HartenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kerri M Winters-StoneDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Miranda J VelthuisNetherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.
Willem van MechelenDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, location: Vrije Universiteit, Amsterdam, The Netherlands.
Marie José KerstenDepartment of Hematology, Amsterdam University Medical Centers, Location University of Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Frans NolletDepartment of Rehabilitation Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Joachim WiskemannWorking Group Exercise Oncology, Division of Medical Oncology, University Clinic Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Laurien M BuffartExercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia. Laurien.Buffart@radboudumc.nl.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLThe Netherlands Cancer Institute · NLAmsterdam University Medical Centers · NLEdith Cowan University · AUGerman Cancer Research Center · DECentral Institute of Mental Health · DEMaastricht University · NLNetherlands Comprehensive Cancer Organisation · NLOncode Institute · NLOregon Health & Science University · USOslo University Hospital · NORadboud University Nijmegen · NLUniversity Hospital Heidelberg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity Medical Center Utrecht · NLUniversity of Amsterdam · NLUniversity of Twente · NLUniversity of Utah · USVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis individual participant data meta-analysis (IPD-MA) assesses exercise effects on self-reported cognitive functioning (CF) and investigates whether effects differ by patient-, intervention-, and exercise-related characteristics.

methodsIPD from 16 exercise RCTs, including 1987 patients across multiple types of non-metastatic cancer, was pooled. A one-stage IPD-MA using linear mixed-effect models was performed to assess exercise effects on self-reported CF (z-score) and to identify whether the effect was moderated by sociodemographic, clinical, intervention- and exercise-related characteristics, or fatigue, depression, anxiety, and self-reported CF levels at start of the intervention (i.e., baseline). Models were adjusted for baseline CF and included a random intercept at study level to account for clustering of patients within studies. A sensitivity analysis was performed in patients who reported cognitive problems at baseline.

resultsMinimal significant beneficial exercise effects on self-reported CF (β=-0.09 [-0.16; -0.02]) were observed, with slightly larger effects when the intervention was delivered post-treatment (n=745, β=-0.13 [-0.24; -0.02]), and no significant effect during cancer treatment (n=1,162, β=-0.08 [-0.18; 0.02]). Larger effects were observed in interventions of 12 weeks or shorter (β=-0.14 [-0.25; -0.04]) or 24 weeks or longer (β=-0.18 [-0.32; -0.02]), whereas no effects were observed in interventions of 12-24 weeks (β=0.01 [-0.13; 0.15]). Exercise interventions were most beneficial when provided to patients without anxiety symptoms (β=-0.10 [-0.19; -0.02]) or after completion of treatment in patients with cognitive problems (β=-0.19 [-0.31; -0.06]). No other significant moderators were identified.

conclusionsThis cross-cancer IPD meta-analysis observed small beneficial exercise effects on self-reported CF when the intervention was delivered post-treatment, especially in patients who reported cognitive problems at baseline. IMPLICATIONS FOR CANCER SURVIVORS: This study provides some evidence to support the prescription of exercise to improve cognitive functioning. Sufficiently powered trials are warranted to make more definitive recommendations and include these in the exercise guidelines for cancer survivors.

Indexed as

Cancer SurvivorsCognitionExerciseNeoplasmsSelf ReportExercise TherapyHumansCancerCognitive functioningExerciseIndividual participant data meta-analysisSurvivorship

Identifiers

PMID37160571
PMCPMC11424665
OpenAlexW4376122137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.