Evidence map›Paper›PMID 37160911›Full record

ArticleScientific data2023

In-depth Temporal Transcriptome Profiling of Monkeypox and Host Cells using Nanopore Sequencing.

Balázs Kakuk, Ákos Dörmő, Zsolt Csabai, Gábor Kemenesi, Jiří Holoubek, Daniel Růžek, István Prazsák, Virág Éva Dani, Béla Dénes, Gábor Torma and 12 more

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Balázs Kakuk *Department of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.ORCID 0000-0002-4314-5707
Ákos Dörmő *Department of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Zsolt CsabaiDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Gábor KemenesiNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Jiří HoloubekVeterinary Research Institute, Hudcova 70, CZ-62100, Brno, Czech Republic.
Daniel RůžekVeterinary Research Institute, Hudcova 70, CZ-62100, Brno, Czech Republic.ORCID 0000-0003-4655-2380
István PrazsákDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Virág Éva DaniDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Béla DénesDepartment of Microbiology and Infectious Diseases, University of Veterinary Medicine Budapest, 1143, Budapest, Hungária krt. 23-25, Hungary.ORCID 0000-0002-9889-529X
Gábor TormaDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Ferenc JakabNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Gábor E TóthNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Fanni V FöldesNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Brigitta ZanaNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Zsófia LanszkiNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Ákos HarangozóDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Ádám FülöpDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Gábor GulyásDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Máté MizikDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
András Attila KissDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.
Dóra TombáczDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary.ORCID 0000-0001-5520-2978
Zsolt BoldogkőiDepartment of Medical Biology, Albert Szent-Györgyi Medical School, University of Szeged, Somogyi u. 4., 6720, Szeged, Hungary. boldogkoi.zsolt@med.u-szeged.hu.ORCID 0000-0003-1184-7293
University of Szeged · HUUniversity of Pecs · HUMasaryk University · CZUniversity of Veterinary Medicine · HU

Funding

Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal (NKFI Office) FK 128252Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal (NKFI Office) K 128247Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal (NKFI Office) K 142674
6 · The paper itself

Abstract

The recent human Monkeypox outbreak underlined the importance of studying basic biology of orthopoxviruses. However, the transcriptome of its causative agent has not been investigated before neither with short-, nor with long-read sequencing approaches. This Oxford Nanopore long-read RNA-Sequencing dataset fills this gap. It will enable the in-depth characterization of the transcriptomic architecture of the monkeypox virus, and may even make possible to annotate novel host transcripts. Moreover, our direct cDNA and native RNA sequencing reads will allow the estimation of gene expression changes of both the virus and the host cells during the infection. Overall, our study will lead to a deeper understanding of the alterations caused by the viral infection on a transcriptome level.

Indexed as

Mpox, MonkeypoxNanopore SequencingDNA, ComplementaryGene Expression ProfilingHumansTranscriptomeDNA, Complementary

Identifiers

PMID37160911
PMCPMC10170163
OpenAlexW4376131021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.