Evidence map›Paper›PMID 37164452›Full record

ArticleBMJ open2023

Burden of opioid toxicity death in the fentanyl-dominant era for people who experience incarceration in Ontario, Canada, 2015-2020: a whole population retrospective cohort study.

Amanda Butler, Ruth Croxford, Claire Bodkin, Hanaya Akbari, Ahmed M Bayoumi, Susan J Bondy, Dale Guenter, Katherine E McLeod, Tara Gomes, Tharsan Kanagalingam and 5 more

Abstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  5. Article
  6. The burden of drug overdose deaths among correctional populations: implications for interventions.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amanda ButlerFamily Medicine, McMaster University, Hamilton, Ontario, Canada butlea17@mcmaster.ca.ORCID 0000-0002-9961-4306
Ruth CroxfordStatistical Consultant, (freelance), Toronto, Ontario, Canada.
Claire BodkinFamily Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9560-1818
Hanaya AkbariFaculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Ahmed M BayoumiMAP Centre for Urban Health Solutions, St. Michael's Hospital, Toronto, Ontario, Canada.
Susan J BondyDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Dale GuenterFamily Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9915-1911
Katherine E McLeodFamily Medicine, McMaster University, Hamilton, Ontario, Canada.
Tara GomesDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Tharsan KanagalingamWestern University Schulich School of Medicine & Dentistry, London, Ontario, Canada.
Lori A KieferOntario Ministry of the Solicitor General, Toronto, Ontario, Canada.
Aaron Michael OrkinFamily and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
Akwasi Owusu-BempahDepartment of Sociology, University of Toronto, Toronto, Ontario, Canada.
Leonora RegenstreifFamily Medicine, McMaster University, Hamilton, Ontario, Canada.
Fiona KouyoumdjianFamily Medicine, McMaster University, Hamilton, Ontario, Canada.

Funding

CIHR SMN-139150
6 · The paper itself

Abstract

objectivesTo describe mortality due to opioid toxicity among people who experienced incarceration in Ontario between 2015 and 2020, during the fentanyl-dominant era.

designIn this retrospective cohort study, we linked Ontario coronial data on opioid toxicity deaths between 2015 and 2020 with correctional data for adults incarcerated in Ontario provincial correctional facilities.

settingOntario, Canada.

participantsWhole population data. MAIN OUTCOMES AND MEASURES: The primary outcome was opioid toxicity death and the exposure was any incarceration in a provincial correctional facility between 2015 and 2020. We calculated crude death rates and age-standardised mortality ratios (SMR).

resultsBetween 2015 and 2020, 8460 people died from opioid toxicity in Ontario. Of those, 2207 (26.1%) were exposed to incarceration during the study period. Among those exposed to incarceration during the study period (n=1 29 152), 1.7% died from opioid toxicity during this period. Crude opioid toxicity death rates per 10 000 persons years were 43.6 (95% CI=41.8 to 45.5) for those exposed to incarceration and 0.95 (95% CI=0.93 to 0.97) for those not exposed. Compared with those not exposed, the SMR for people exposed to incarceration was 31.2 (95% CI=29.8 to 32.6), and differed by sex, at 28.1 (95% CI=26.7 to 29.5) for males and 77.7 (95% CI=69.6 to 85.9) for females. For those exposed to incarceration who died from opioid toxicity, 10.6% died within 14 days of release and the risk was highest between days 4 and 7 postrelease, at 288.1 per 10 000 person years (95% CI=227.8 to 348.1).

conclusionsThe risk of opioid toxicity death is many times higher for people who experience incarceration compared with others in Ontario. Risk is markedly elevated in the week after release, and women who experience incarceration have a substantially higher SMR than men who experience incarceration. Initiatives to prevent deaths should consider programmes and policies in correctional facilities to address high risk on release.

Indexed as

Opioid-Related DisordersPrisonersAdultAnalgesics, OpioidCorrectional FacilitiesFemaleFentanylHumansMaleOntarioRetrospective StudiesAnalgesics, OpioidFentanylEPIDEMIOLOGIC STUDIESHealth policyPUBLIC HEALTHSubstance misuse

Identifiers

PMID37164452
PMCPMC10186413

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.