ReviewExperimental neurobiology2023
Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders.
Review in Experimental neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Influence of Lycopene Intake on Mental Health: A Systematic Review of Randomized Controlled Trials (RCTs).Nutrients · 2025Pooled it
- ApoE4 as a Therapeutic Target in Epilepsy: From Pathogenic Mechanisms to Precision Medicine.CNS neuroscience & therapeutics · 2026Review
- Atherogenic Index of Plasma for the Prediction of Delirium in ICU Patients: A Retrospective Cohort Study Based on the MIMIC-IV Database.Brain and behavior · 2026Article
- The total cholesterol to high-density lipoprotein cholesterol ratio predicts post-stroke depression: linear association and individualized risk nomogram.Lipids in health and disease · 2026Article
- Nonlinear association of the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio with cognitive function in older Chinese adults: A prospective cohort study.The Journal of international medical research · 2026Article
- Lipidomic and sterolomic profiles of different brain regions in the mouse model of Alzheimer's disease.Neural regeneration research · 2026Article
- DHCR24 in cholesterol metabolism and diseases of the nervous system.Lipids in health and disease · 2026Review
- Pharmacological evaluation of Lonafarnib in reversing neurobehavioral, neurochemical and metabolic deficit in mouse models of chronic unpredictable mild stress (CUMS).Metabolic brain disease · 2026Article
- Association between Apolipoprotein B (ApoB) and suicidal ideation: a cross-sectional study and Mendelian randomization analysis.Annals of general psychiatry · 2026Article
- The Role of Cholesterol at the CHOL2 Site and the Dimeric Interface in the Regulation of Serotonin Transporter Function and Dimerization.Biomolecules · 2026Article
- Association Between Preoperative Malnutrition Assessed by the Controlling Nutritional Status (CONUT) Score and Postoperative Delirium in Elderly Patients with Hip Fractures: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Real-World Evidence on Statin Use for Traumatic Brain Injury Associated Degenerative Neurological Disorders.Therapeutics and clinical risk management · 2026Article
- Gut microbiota and metabolic characteristics in subthreshold depression based on multi-omics.Frontiers in psychiatry · 2026Article
- Role of LXRβ in oligodendrocytes in neuronal survival.Molecular psychiatry · 2026Article
- Towards precision psychiatry: Metabolomics identifies three biological subtypes of depression.PLOS digital health · 2025Article
- Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- [Role of dysregulation brain lipid metabolism in depression].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.Nature communications · 2025Article
- Contrasting Effects of Clozapine and Risperidone on Cholesterol Metabolism, Synaptic Proteins, and Transcriptional Regulation in Human LUHMES Neurons.Molecular neurobiology · 2025Article
- TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects.Acta neuropathologica · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol metabolism plays an essential role in cellular functions (including as a component of the plasma membrane, as an energy source, and in hormone production) under normal conditions. Dysregulated cholesterol metabolism causes a wide spectrum of pathological conditions, leading to neuropsychiatric disorders, such as anxiety and depression. In addition, patients with neuropsychiatric disorders also have impaired cholesterol metabolism. Therefore, metabolic disturbances are closely associated with the neuropsychiatric disorders. Although immune disturbance, neuroinflammation, a dysregulated neurotransmitter system, and oxidative stress have been suggested as pathophysiology of neuropsychiatric disorders, dysregulation of cholesterol metabolism is also found in patients with psychiatric diseases. As expected, patients with mental illness appear to be at risk of metabolic disorders, including metabolic syndrome, in which cholesterol influences altered neuronal homeostasis, such as neuronal cell toxicity, neuronal cell death, and neuronal structures and functions, including synaptogenesis, neurogenesis, axonogenesis, and action potential. Therefore, reversing impaired or abnormal cholesterol metabolism may help restore neuronal injury found in mental illness. This review is aimed to discuss the links between cholesterol metabolism impairment and neuropsychiatric disorders and provides insights into neuronal dysfunction due to abnormal cholesterol metabolism in neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.