Evidence map›Paper›PMID 37165253›Full record

ArticleCardiovascular engineering and technology2023

Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device.

Amarnath Sangeetha Menon, Igor Subasic de Azevedo, Kylie Choong, Dhruv Bhatnagar, Chen Wang, Pavel Sluka, David R Chisholm, Paul Pasic, Helmut Thissen, Gopal Sama and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Amarnath Sangeetha MenonEastern Health Clinical School, Monash University, Melbourne, Australia.
Igor Subasic de AzevedoEastern Health Clinical School, Monash University, Melbourne, Australia.
Kylie ChoongEastern Health Clinical School, Monash University, Melbourne, Australia.
Dhruv BhatnagarEastern Health Clinical School, Monash University, Melbourne, Australia.
Chen WangEastern Health Clinical School, Monash University, Melbourne, Australia.
Pavel SlukaEastern Health Clinical School, Monash University, Melbourne, Australia.
David R ChisholmLightOx Ltd, Newcastle Upon Tyne, UK.
Paul PasicCSIRO Biomedical Materials Translational Facility, Melbourne, Australia.
Helmut ThissenCSIRO Biomedical Materials Translational Facility, Melbourne, Australia.
Gopal SamaSchool of Chemistry, Monash University, Melbourne, Australia.
Andrea RobinsonSchool of Chemistry, Monash University, Melbourne, Australia.
Andrew RoddaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Aldous TriaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Loren SpiegelMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Anak DharmaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Harikrishnan KaipananickalMonash University Department of Diabetes, Monash University, Melbourne, Australia.
Jun OkabeMonash University Department of Diabetes, Monash University, Melbourne, Australia.
Assam El-OstaMonash University Department of Diabetes, Monash University, Melbourne, Australia.
Simon MountfordMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Philip ThompsonMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Anthony E DearEastern Health Clinical School, Monash University, Melbourne, Australia. Anthony.dear@monash.edu.ORCID 0000-0001-7832-2294
Monash University · AUEastern Health · AUCommonwealth Scientific and Industrial Research Organisation · AUBox Hill Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Lumi-Solve photo-angioplasty drug eluting balloon catheter (DEBc) may afford safety advantages over current DEBc. Lumi-Solve utilises the guidewire (GW) port and lumen to deliver fibre-optic UV365nm light to the angioplasty balloon which may be problematic. We explore and evaluate alternative Lumi-Solve design options to circumvent fibre-optic use of the GW port and lumen which may enhance efficacy and clinical utility.

methodsEffects of guidewire shadowing (GWS) on visible and UV365nm light transmission were evaluated and modelled in-silico. To evaluate the effect of a dedicated intra-balloon fibre-optic port, modified angioplasty balloons and sections of translucent polyethylene terephthalate (PET) GW port tubing were utilised. Investigation of the effect of GWS on chemical and biological photo-activation of balloon surface drug was performed utilising LCMS analysis and inhibition of histone deacetylase activity (HDACi) was measured in human umbilical vein endothelial cells (HUVEC).

resultsParallel fibre-optic and GW port configurations generated a GWS of approximately 18.0% of the evaluable balloon surface area and attenuated both visible and UV light intensity by 20.0-25.0% and reduced chemical photo-activation of balloon surface drug and HDACi by at least 40-45%. Alternative fibre-optic port configurations including a spiral design significantly mitigated GWS effects on UV light transmission.

conclusionsTo avoid use of the GW port and its associated complications a dedicated third port and lumen for the Lumi-Solve fibre-optic may be required. To maximize balloon surface chemical and biological photo-activation, non-parallel, intra-balloon, fibre-optic lumen trajectories, including a spiral design may be useful.

Indexed as

Angioplasty, BalloonVascular Access DevicesHumansHuman Umbilical Vein Endothelial CellsDrug eluting balloon catheterFibre-opticGuide wire shadowNeointimal hyperplasiaPhoto-activation

Identifiers

PMID37165253
PMCPMC10465377
OpenAlexW4376132724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.