Evidence map›Paper›PMID 37168562›Full record

ArticleiScience2023

Evaluating the transcriptional landscape and cell-cell communication networks in chronically irradiated parotid glands.

Brenna A Rheinheimer, Mary C Pasquale, NIDCD/NIDCR Genomics and Computational Biology Core, Kirsten H Limesand, Matthew P Hoffman, Alejandro M Chibly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brenna A RheinheimerNutritional Sciences Department, University of Arizona, Tucson, AZ 85721, USA.
Mary C PasqualeMatrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
NIDCD/NIDCR Genomics and Computational Biology Core
Kirsten H LimesandNutritional Sciences Department, University of Arizona, Tucson, AZ 85721, USA.
Matthew P HoffmanMatrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Alejandro M ChiblyMatrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
National Institutes of Health · USUniversity of Arizona · USNational Institute of Dental and Craniofacial Research · US

Funding

Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
Progenitor/Stem Cell Function During Salivary Gland DevelopmentZIADE000722 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$13.7M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
INTEGRATIVE MECHANISMS OF CORTICAL NEURONSR01DC000086 · NIDCD · YALE UNIVERSITY · PI SHEPHERD, GORDON · 1989 to 2010
$3.6M
Ineffective wound healing responses enable chronic radiation-induced salivary gland dysfunctionR01DE029166 · NIDCR · UNIVERSITY OF ARIZONA · PI LIMESAND, KIRSTEN H · 2019 to 2023
$1.7M
Intramural NIH HHS ZIG DE000740NIDCD NIH HHS R01 DC000086NIDCR NIH HHS R01 DE029166
6 · The paper itself

Abstract

Understanding the transcriptional landscape that results in chronic salivary hypofunction after irradiation will help identify injury mechanisms and develop regenerative therapies. We present scRNA-seq analysis from control and irradiated murine parotid glands collected 10 months after irradiation. We identify a population of secretory cells defined by specific expression of

Indexed as

Cell biologyImmunologyTranscriptomics

Identifiers

PMID37168562
PMCPMC10165028
OpenAlexW4364380774

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.