Evidence map›Paper›PMID 37172398›Full record

ArticlePsychiatry research2023

Child and adolescent psychiatrists' use, attitudes, and understanding of genetic testing and pharmacogenetics in clinical practice.

Takahiro Soda, Amanda R Merner, Brent J Small, Laura N Torgerson, Katrina Muñoz, Jehannine Austin, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz

Abstract read
In one paragraph

Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision-Making and Polygenic Embryo Screening.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Takahiro SodaDepartment of Psychiatry, University of Florida, Gainesville, FL, United States of America; Center for Autism and Neurodevelopment, University of Florida, Gainesville, Florida, United States of America.
Amanda R MernerCenter for Bioethics, Harvard Medical School, Boston, Massachusetts, United States of America.
Brent J SmallSchool of Aging Studies, University of South Florida, Tampa, FL, United States of America.
Laura N TorgersonCTMC, Houston, TX, United States of America.
Katrina MuñozSchool of Medicine, Emory University, Atlanta, Georgia, United States of America.
Jehannine AustinDepartment of Psychiatry, University of British Columbia, Vancouver, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Eric A StorchDepartment of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America.
Stacey PereiraCenter for Medical Ethics & Health Policy at Baylor College of Medicine.
Gabriel Lázaro-MuñozCenter for Bioethics, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Electronic address: glazaro@hms.harvard.edu.

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Polygenic Risk Scores in Child and Adolescent Psychiatry: Ethical, Clinical, and Legal ImplicationsR01MH128676 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI LAZARO-MUNOZ, GABRIEL, PEREIRA, STACEY · 2021 to 2024
$2.5M
Return of Results from Psychiatric Genomics Research: Attitudes and BarriersR00HG008689 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LAZARO-MUNOZ, GABRIEL · 2017 to 2019
$905k
NHGRI NIH HHS R00 HG008689NICHD NIH HHS P50 HD103555NIMH NIH HHS R01 MH128676
6 · The paper itself

Abstract

The purpose of this study was to report current practices and attitudes of child and adolescent psychiatrists (CAP) regarding diagnostic genetic and pharmacogenetic (PGx) testing. We surveyed 958 US-based practicing CAP. 54.9% of respondents indicated that they had ordered/referred for a genetic test in the past 12 months. 87% of respondents agreed that it is their role to discuss genetic information regarding psychiatric conditions with their patients; however, 45% rated their knowledge of genetic testing practice guidelines as poor/very poor. The most ordered test was PGx (32.2%), followed by chromosomal microarray (23.0%). 73.4% reported that PGx is at least slightly useful in child and adolescent psychiatry. Most (62.8%) were asked by a patient/family to order PGx in the past 12 months and 41.7% reported they would order PGx in response to a family request. Those who ordered a PGx test were more likely to have been asked by a patient/family and to work in private practice. 13.8% of respondents agreed/strongly agreed that a PGx test can predict the effectiveness of specific antidepressants. Some respondents also indicated they would make clinical changes based on PGx information even if a medication was currently effective and there were no side effects. Genetic testing has become routine clinical care in child and adolescent psychiatry. Despite this, many providers rate their associated knowledge as poor/very poor. Patient requests were associated with ordering practices and providers misinterpretation of PGx may be leading to unnecessary changes in clinical management. There is need for further education and support for clinicians.

Indexed as

PharmacogeneticsPsychiatryAdolescentAdolescent PsychiatryChildGenetic TestingHealth Knowledge, Attitudes, PracticeHumansChild and adolescent psychiatryEthicsGeneticsGenetic testingPractice patternsPsychopharmacologySurvey

Identifiers

PMID37172398
PMCPMC10365566

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.