Evidence map›Paper›PMID 37174704›Full record

ArticleCells2023

Long-Term Treatment with Gadopentetic Acid or Gadodiamide Increases TRPC5 Expression and Decreases Adriamycin Nuclear Accumulation in Breast Cancer Cells.

Weiheng Zhang, Mengyuan Wang, Weizhen Lv, Fletcher A White, Xingjuan Chen, Alexander G Obukhov

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Weiheng ZhangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.
Mengyuan WangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.
Weizhen LvXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.ORCID 0000-0001-8820-5120
Fletcher A WhiteStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Xingjuan ChenXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.ORCID 0000-0002-7380-8399
Alexander G ObukhovStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3862-6004
Northwestern Polytechnical University · CNIndiana University School of MedicineQinghai University · CN

Funding

TRPC Channels in the Metabolic SyndromeR01HL115140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2012 to 2016
$2.6M
The role of cell-specific TLR-4 signaling in oxaliplatin-induced peripheral neuropathyR01NS102415 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WHITE, FLETCHER A · 2018 to 2022
$2.2M
Molecular Physiology of TRPC ChannelsR01HL083381 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2006 to 2010
$1.8M
NHLBI NIH HHS R01 HL083381NHLBI NIH HHS R01 HL115140NINDS NIH HHS R01 NS102415
6 · The paper itself

Abstract

Gadopentetic acid and gadodiamide are paramagnetic gadolinium-based contrast agents (GBCAs) that are routinely used for dynamic contrast-enhanced magnetic resonance imaging (MRI) to monitor disease progression in cancer patients. However, growing evidence indicates that repeated administration of GBCAs may lead to gadolinium (III) cation accumulation in the cortical bone tissue, skin, basal ganglia, and cerebellum, potentially leading to a subsequent slow long-term discharge of Gd

Indexed as

Breast NeoplasmsOrganometallic CompoundsContrast MediaDoxorubicinFemaleGadoliniumGadolinium DTPAHEK293 CellsHumansTRPC Cation ChannelsContrast MediaDoxorubicingadodiamideGadoliniumGadolinium DTPAOrganometallic CompoundsTRPC5 protein, humanTRPC Cation Channelsbreast cancerchemotherapy resistanceGBCAsTRPC5

Identifiers

PMID37174704
PMCPMC10177392
OpenAlexW4368367570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.