Evidence map›Paper›PMID 37175276›Full record

ArticleMolecules (Basel, Switzerland)2023

Novel Indoline Spiropyrans Based on Human Hormones β-Estradiol and Estrone: Synthesis, Structure, Chromogenic and Cytotoxic Properties.

Ilya V Ozhogin, Artem D Pugachev, Nadezhda I Makarova, Anna A Belanova, Anastasia S Kozlenko, Irina A Rostovtseva, Peter V Zolotukhin, Oleg P Demidov, Islam M El-Sewify, Gennady S Borodkin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ilya V OzhoginInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.ORCID 0000-0002-9546-7513
Artem D PugachevInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Nadezhda I MakarovaInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Anna A BelanovaAcademy of Biology and Biotechnology, Southern Federal University, 194/1 Stachka Ave., 344090 Rostov-on-Don, Russia.
Anastasia S KozlenkoInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Irina A RostovtsevaInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Peter V ZolotukhinAcademy of Biology and Biotechnology, Southern Federal University, 194/1 Stachka Ave., 344090 Rostov-on-Don, Russia.
Oleg P DemidovFaculty of Chemistry and Pharmacy, North-Caucasus Federal University, 1 Pushkina Str., 355000 Stavropol, Russia.
Islam M El-SewifyDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0003-1934-4260
Gennady S BorodkinInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Anatoly V MetelitsaInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.ORCID 0000-0003-3645-5528
Boris S LukyanovInstitute of Physical and Organic Chemistry, Southern Federal University, 194/2 Stachka Ave., 344090 Rostov-on-Don, Russia.
Southern Federal University · RUAin Shams University · EGNorth-Caucasus Federal University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation RF-2296.61321X0029, no. 075-15-2021-687Russian Science Foundation 21-73-10300
6 · The paper itself

Abstract

The introduction of a switchable function into the structure of a bioactive compound can endow it with unique capabilities for regulating biological activity under the influence of various types of external stimuli, which makes such hybrid compounds promising objects for photopharmacology, targeted drug delivery and bio-imaging. This work is devoted to the synthesis and study of new spirocyclic derivatives of important human hormones-β-estradiol and estrone-possessing a wide range of biological activities. The obtained hybrid compounds represent an indoline spiropyrans family, a widely known class of organic photochromic compounds. The structure of the compounds was confirmed by

Indexed as

EstradiolEstroneBenzopyransHeLa CellsHumansIndolesNitro CompoundsBenzopyransEstradiolEstroneIndolesindolineNitro Compoundsspiropyranacidochromismcytotoxicitymolecular switchsingle-crystal X-ray analysisspiropyranβ-estradiol

Identifiers

PMID37175276
PMCPMC10179760
OpenAlexW4376630394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.