Evidence mapPaperPMID 37175603Full record

ReviewInternational journal of molecular sciences2023

Mechanisms of Oxidative Stress in Metabolic Syndrome.

Sepiso K Masenga, Lombe S Kabwe, Martin Chakulya, Annet Kirabo

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 373 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 10 pooled it
113.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 10 syntheses or guidelines pooled it, 568 citations in OpenAlex.

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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sepiso K MasengaHAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia.ORCID 0000-0003-4376-5831
Lombe S KabweHAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia.
Martin ChakulyaHAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia.
Annet KiraboDepartment of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA.ORCID 0000-0001-8580-9359
Mulungushi University · ZMVanderbilt University Medical Center · US

Funding

ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 to 2025
$2.0M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$572k
UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2)D43TW009744 · UNIVERSITY OF ZAMBIA · 2025 to 2025
$112k
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seqR03HL155041 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Annet Kirabo Kirabo · 2022 to 2022
$87k
FIC NIH HHS D43 TW009744FIC NIH HHS R03HL155041, R01HL147818, and R01HL144941 (AK) and 2D43TW009744 (SKM).NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL147818NHLBI NIH HHS R03 HL155041
6 · The paper itself

Abstract

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceMetabolic SyndromeHumansInflammationObesityOxidative Stresscardiovascular diseasehyperglycemiahyperlipidemiahypertensioninflammatory cytokinesinsulin resistancemetabolic syndromeobesityoxidative stress

Identifiers

PMID37175603
PMCPMC10178199
OpenAlexW4367182956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.