Evidence map›Paper›PMID 37175699›Full record

ReviewInternational journal of molecular sciences2023

The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson's Disease.

Jingwen Li, Yanli Xu, Tingting Liu, Yuxiang Xu, Xiantao Zhao, Jianshe Wei

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Neuroplasticity in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jingwen LiDepartment of Kinesiology, School of Physical Education, Henan University, Kaifeng 475000, China.
Yanli XuInstitute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Tingting LiuInstitute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Yuxiang XuInstitute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Xiantao ZhaoDepartment of Kinesiology, School of Physical Education, Henan University, Kaifeng 475000, China.
Jianshe WeiDepartment of Kinesiology, School of Physical Education, Henan University, Kaifeng 475000, China.ORCID 0000-0002-3560-3392
Henan University · CN

Funding

Bio-Med Interdisciplinary Innovative Program of Henan University CJ1205A0240018Henan Province Natural Science Foundation of China 182300410313National Natural Science Foundation of China 81271410
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common rapidly progressive neurodegenerative disease and has serious health and socio-economic consequences. Mitochondrial dysfunction is closely related to the onset and progression of PD, and the use of mitochondria as a target for PD therapy has been gaining traction in terms of both recognition and application. The disruption of mitochondrial proteostasis in the brain tissue of PD patients leads to mitochondrial dysfunction, which manifests as mitochondrial unfolded protein response, mitophagy, and mitochondrial oxidative phosphorylation. Physical exercise is important for the maintenance of human health, and has the great advantage of being a non-pharmacological therapy that is non-toxic, low-cost, and universally applicable. In this review, we investigate the relationships between exercise, mitochondrial proteostasis, and PD and explore the role and mechanisms of mitochondrial proteostasis in delaying PD through exercise.

Indexed as

Neurodegenerative DiseasesParkinson DiseaseExerciseHumansMitochondriaProteostasisexercisemitochondriamitochondrial proteostasisneurodegenerative diseaseParkinson’s disease

Identifiers

PMID37175699
PMCPMC10179072
OpenAlexW4367316023

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.