Evidence map›Paper›PMID 37175848›Full record

ArticleInternational journal of molecular sciences2023

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma.

Prasoon Agarwal, Aleksandra Glowacka, Loay Mahmoud, Wesam Bazzar, Lars-Gunnar Larsson, Mohammad Alzrigat

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Prasoon AgarwalNational Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 22362 Lund, Sweden.ORCID 0000-0003-1813-7606
Aleksandra GlowackaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Solna, Sweden.
Loay MahmoudDepartment of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Wesam BazzarDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Solna, Sweden.
Lars-Gunnar LarssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Solna, Sweden.
Mohammad AlzrigatDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Solna, Sweden.ORCID 0000-0001-5514-8625
Uppsala University · SEKarolinska Institutet · SELund University · SE

Funding

Barncancerfonden TJ2019-0018; PR2019-0063Lillian Sagens och Curt Ericssons Forskningsstiftelse 2022-MANovonordisk foundation LGLOE och Edla Johanssons vetenskapliga stiftelse MA-2020, MA-2021, MA-2022Swedish Cancer Society NA
6 · The paper itself

Abstract

Amplification of the

Indexed as

Amyloid Precursor Protein SecretasesNeuroblastomaCell LineCell Line, TumorGene AmplificationGene Expression Regulation, NeoplasticHumansMembrane ProteinsN-Myc Proto-Oncogene ProteinSignal TransductionAmyloid Precursor Protein SecretasesMembrane ProteinsN-Myc Proto-Oncogene ProteinMYCNMYCN amplificationneuroblastomaNOTCH signalingγ-secretase

Identifiers

PMID37175848
PMCPMC10179553
OpenAlexW4368377152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.