Evidence map›Paper›PMID 37176017›Full record

ArticleInternational journal of molecular sciences2023

Risk Effects of rs1799945 Polymorphism of the

Tatiana Ivanova, Maria Churnosova, Maria Abramova, Irina Ponomarenko, Evgeny Reshetnikov, Inna Aristova, Inna Sorokina, Mikhail Churnosov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Polymorphism of theLife (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.International journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tatiana IvanovaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Maria ChurnosovaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0001-6444-8806
Maria AbramovaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Irina PonomarenkoDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Evgeny ReshetnikovDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Inna AristovaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Inna SorokinaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Mikhail ChurnosovDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0003-1254-6134
Belgorod National Research University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this case-control replicative study was to investigate the link between GWAS-impact for arterial hypertension (AH) and/or blood pressure (BP) gene polymorphisms and AH risk in Russian subjects (Caucasian population of Central Russia). AH (n = 939) and control (n = 466) cohorts were examined for ten GWAS AH/BP risk loci. The genotypes/alleles of these SNP and their combinations (SNP-SNP interactions) were tested for their association with the AH development using a logistic regression statistical procedure. The genotype GG of the SNP rs1799945 (C/G) HFE was strongly linked with an increased AH risk (ORrecGG = 2.53; 95%CIrecGG1.03-6.23; ppermGG = 0.045). The seven SNPs such as rs1173771 (G/A)

Indexed as

Genome-Wide Association StudyHypertensionCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHemochromatosis ProteinHumansMolecular ChaperonesPlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideRussiaATP2B1 protein, humanBAG6 protein, humanHemochromatosis ProteinHFE protein, humanMolecular ChaperonesPlasma Membrane Calcium-Transporting ATPasesarterial hypertensionassociationhypertension/blood pressure genesSNP

Identifiers

PMID37176017
PMCPMC10179076
OpenAlexW4376631212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.