Evidence map›Paper›PMID 37177013›Full record

ArticleNanomaterials (Basel, Switzerland)2023

Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances.

Dagmara Słota, Karina Piętak, Wioletta Florkiewicz, Josef Jampilek, Agnieszka Tomala, Mateusz M Urbaniak, Agata Tomaszewska, Karolina Rudnicka, Agnieszka Sobczak-Kupiec

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Exploring the Osteoinductive Potential of Bacterial Pyomelanin Derived fromInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dagmara SłotaDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31 864 Krakow, Poland.ORCID 0000-0002-8570-3594
Karina PiętakDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31 864 Krakow, Poland.ORCID 0000-0001-7970-3478
Wioletta FlorkiewiczDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31 864 Krakow, Poland.ORCID 0000-0002-9392-4362
Josef JampilekDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0003-2003-9052
Agnieszka TomalaDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31 864 Krakow, Poland.ORCID 0000-0002-2327-3947
Mateusz M UrbaniakDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-237 Łódź, Poland.ORCID 0000-0002-2800-2054
Agata TomaszewskaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-237 Łódź, Poland.ORCID 0000-0003-4290-4115
Karolina RudnickaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-237 Łódź, Poland.ORCID 0000-0002-3412-9000
Agnieszka Sobczak-KupiecDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31 864 Krakow, Poland.ORCID 0000-0003-0005-6146

Funding

Foundation for Polish Science POIR.04.04.00-00-16D7/18
6 · The paper itself

Abstract

Bioactive calcium phosphate ceramics (CaPs) are one of the building components of the inorganic part of bones. Synthetic CaPs are frequently used as materials for filling bone defects in the form of pastes or composites; however, their porous structure allows modification with active substances and, thus, subsequent use as a drug carrier for the controlled release of active substances. In this study, four different ceramic powders were compared: commercial hydroxyapatite (HA), TCP, brushite, as well as HA obtained by wet precipitation methods. The ceramic powders were subjected to physicochemical analysis, including FTIR, XRD, and determination of Ca/P molar ratio or porosity. These techniques confirmed that the materials were phase-pure, and the molar ratios of calcium and phosphorus elements were in accordance with the literature. This confirmed the validity of the selected synthesis methods. CaPs were then modified with the antibiotic clindamycin. Drug release was determined on HPLC, and antimicrobial properties were tested against

Indexed as

antibioticbrushitecalcium phosphatesceramicsclindamycindrug delivery systemhydroxyapatite

Identifiers

PMID37177013
PMCPMC10180150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.