Evidence map›Paper›PMID 37178405›Full record

ArticleProbiotics and antimicrobial proteins2023

Probiotic-Derived Ecto-5'-Nucleotidase Produces Anti-Inflammatory Adenosine Metabolites in Treg-Deficient Scurfy Mice.

Yuying Liu, Shabba A Armbrister, Beanna Okeugo, Tingting W Mills, Rhea C Daniel, Jee-Hwan Oh, Jan-Peter van Pijkeren, Evelyn S Park, Zeina M Saleh, Sharmistha Lahiri and 2 more

Open access · greenAbstract read
In one paragraph

Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Gut microbes · 2026
    Article
  3. Article
  4. Frontiers in immunology · 2026
    Article
  5. Gut microbes · 2025
    Review
  6. Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine- and enterocyte-derived hormones.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Article
  8. Article
  9. bioRxiv : the preprint server for biology · 2024
    Article
  10. Applied and environmental microbiology · 2024
    Article
  11. ProbioticNutrients · 2024
    Article
  12. Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yuying LiuDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Yuying.Liu@uth.tmc.edu.ORCID 0000-0003-3848-9254
Shabba A ArmbristerDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Beanna OkeugoDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Tingting W MillsDepartment of Biochemistry & Molecular Biology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Rhea C DanielDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Jee-Hwan OhDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jan-Peter van PijkerenDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Evelyn S ParkDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Zeina M SalehDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Sharmistha LahiriDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Stefan RoosDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
JMarc RhoadsDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
The University of Texas Health Science Center at Houston · USUniversity of Wisconsin–Madison · USSwedish University of Agricultural Sciences · SEThe University of Texas Health Science Center · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
CFlm25 mediated alternative polyadenylation regulates fibrosis in systemic sclerosisR01AR073284 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ASSASSI, SHERVIN, MILLS, TINGTING WENG · 2019 to 2023
$1.7M
Regulatory role of APA in pulmonary fibrosis during agingR56AG076144 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHEN, ZHENG, MILLS, TINGTING WENG · 2022 to 2022
$320k
Lactobacillus reuteri treatment for Treg-deficiency Autoimmune DiseaseR03AI117442 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING · 2015 to 2016
$160k
Impact of probiotic-mediated adenosine metabolism in regulating immune dysfunction.R03AI153725 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING · 2020 to 2021
$156k
NIAID NIH HHS R03 AI117442NIAID NIH HHS R03 AI153725NIAMS NIH HHS R01 AR073284NIA NIH HHS R56 AG076144NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Probiotic Limosilactobacillus reuteri DSM 17938 (DSM 17938) prolongs the survival of Treg-deficient scurfy (SF) mice and reduces multiorgan inflammation by a process requiring adenosine receptor 2A (A

Indexed as

5'-NucleotidaseAdenosineAnimalsAnti-Inflammatory AgentsCD8-Positive T-LymphocytesHumansInosineMiceT-Lymphocytes, Regulatory5'-NucleotidaseAdenosineAnti-Inflammatory AgentsInosineAutoimmunityCD73IPEX syndromeLimosilactobacillus reuteriRegulatory T cellTreg deficiency

Identifiers

PMID37178405
PMCPMC10926147
OpenAlexW4376504074

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.