Evidence map›Paper›PMID 37180990›Full record

ArticleBrain communications2023

Shared imaging markers of fatigue across multiple sclerosis, aquaporin-4 antibody neuromyelitis optica spectrum disorder and MOG antibody disease.

Valentina Camera, Romina Mariano, Silvia Messina, Ricarda Menke, Ludovica Griffanti, Matthew Craner, Maria I Leite, Massimiliano Calabrese, Stefano Meletti, Ruth Geraldes and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Valentina CameraNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.ORCID https://orcid.org/0000-0002-4925-9000
Romina MarianoNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Silvia MessinaNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Ricarda MenkeNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Ludovica GriffantiWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Matthew CranerNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Maria I LeiteNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Massimiliano CalabreseDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37124 Verona, Italy.
Stefano MelettiDepartment of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID https://orcid.org/0000-0003-0334-539X
Ruth GeraldesNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
Jacqueline A PalaceNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU Oxford, UK.
University of Oxford · GBWexham Park Hospital · GBUniversity of Verona · ITUniversity of Modena and Reggio Emilia · IT

Funding

Wellcome Trust
6 · The paper itself

Abstract

Fatigue is frequently reported by patients with multiple sclerosis, aquaporin-4-antibody neuromyelitis optica spectrum disorder and myelin-oligodendrocyte-glycoprotein antibody disease; thus they could share a similar pathophysiological mechanism. In this cross-sectional cohort study, we assessed the association of fatigue with resting-state functional MRI, diffusion and structural imaging measures across these three disorders. Sixteen patients with multiple sclerosis, 17 with aquaporin-4-antibody neuromyelitis optica spectrum disorder and 17 with myelin-oligodendrocyte-glycoprotein antibody disease assessed, outside of relapses, at the Oxford Neuromyelitis Optica Service underwent Modified Fatigue Impact Scale, Hospital Anxiety and Depression Scale and Expanded Disability Status Scale scoring. A 3T brain and spinal cord MRI was used to derive cortical, deep grey and white matter volumetrics, lesions volume, fractional anisotropy, brain functional connectivity metrics, cervical spinal cord cross-sectional area, spinal cord magnetic transfer ratio and average functional connectivity between the ventral and the dorsal horns of the cervical cord. Linear relationships between MRI measures and total-, cognitive- and physical-fatigue scores were assessed. All analyses were adjusted for correlated clinical regressors. No significant differences in baseline clinical characteristics, fatigue, depression and anxiety questionnaires and disability measures were seen across the three diseases, except for older age in patients with aquaporin-4-antibody neuromyelitis optica spectrum disorder (

Indexed as

aquaporin-4 neuromyelitis optica spectrum disordersfatigueMOG-antibody diseasemultiple sclerosisresting-state functional MRI

Identifiers

PMID37180990
PMCPMC10171455
OpenAlexW4362592918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.