Evidence map›Paper›PMID 37181817›Full record

ReviewBioMed research international2023

Next-Generation Vaccines: Nanovaccines in the Fight against SARS-CoV-2 Virus and beyond SARS-CoV-2.

Maluta Steven Mufamadi, Mpho Phehello Ngoepe, Ofentse Nobela, Nhlanhla Maluleke, Bafedile Phorah, Banele Methula, Thapelo Maseko, Dipuo Ingrid Masebe, Hazel Tumelo Mufhandu, Lebogang Maureen Katata-Seru

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maluta Steven MufamadiDSI-Mandela Nanomedicine Platform, Nelson Mandela University, Gqeberha 6059, South Africa.ORCID https://orcid.org/0000-0002-2112-7137
Mpho Phehello NgoepeDSI-Mandela Nanomedicine Platform, Nelson Mandela University, Gqeberha 6059, South Africa.ORCID https://orcid.org/0000-0001-7682-9489
Ofentse NobelaNabio Consulting (Pty) Ltd., Pretoria 0183, South Africa.
Nhlanhla MalulekeNabio Consulting (Pty) Ltd., Pretoria 0183, South Africa.
Bafedile PhorahNabio Consulting (Pty) Ltd., Pretoria 0183, South Africa.
Banele MethulaNabio Consulting (Pty) Ltd., Pretoria 0183, South Africa.
Thapelo MasekoDSI-Mandela Nanomedicine Platform, Nelson Mandela University, Gqeberha 6059, South Africa.
Dipuo Ingrid MasebeNabio Consulting (Pty) Ltd., Pretoria 0183, South Africa.
Hazel Tumelo MufhanduDepartment of Microbiology, North-West University, Mafikeng 2745, South Africa.
Lebogang Maureen Katata-SeruDepartment of Chemistry, North-West University, Mafikeng 2745, South Africa.
Nelson Mandela University · ZANorth-West University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The virus responsible for the coronavirus viral pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emerging SARS-CoV-2 variants caused by distinctive mutations within the viral spike glycoprotein of SARS-CoV-2 are considered the cause for the rapid spread of the disease and make it challenging to treat SARS-CoV-2. The manufacturing of appropriate efficient vaccines and therapeutics is the only option to combat this pandemic. Nanomedicine has enabled the delivery of nucleic acids and protein-based vaccines to antigen-presenting cells to produce protective immunity against the coronavirus. Nucleic acid-based vaccines, particularly mRNA nanotechnology vaccines, are the best prevention option against the SARS-CoV-2 pandemic worldwide, and they are effective against the novel coronavirus and its multiple variants. This review will report on progress made thus far with SARS-CoV-2 vaccines and beyond employing nanotechnology-based nucleic acid vaccine approaches.

Indexed as

COVID-19Viral VaccinesCOVID-19 VaccinesHumansSARS-CoV-2COVID-19 VaccinesViral Vaccines

Identifiers

PMID37181817
PMCPMC10175023
OpenAlexW4368341633

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.