Evidence map›Paper›PMID 37184573›Full record

ArticleDevelopment genes and evolution2023

Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function.

Dhyanam Shukla, Brian M Gural, Edmund S Cauley, Namarata Battula, Shorbon Mowla, Brittany F Karas, Llion E Roberts, Luca Cavallo, Luka Turkalj, Sally A Moody and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development genes and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Dhyanam Shukla *Department of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Brian M Gural *Department of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Edmund S Cauley *Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Namarata BattulaDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Shorbon MowlaDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Brittany F KarasDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Llion E RobertsInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Luca CavalloDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Luka TurkaljDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA.
Sally A MoodyDepartment of Anatomy and Cell Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Laura E SwanInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
M Chiara ManziniDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, CHINJ Rm 3274, New Brunswick, NJ, 08901, USA. chiara.manzini@rutgers.edu.
Johnson University · USRutgers, The State University of New Jersey · USGeorge Washington University · USUniversity of Liverpool · GB

Funding

Identification of Genetic and Molecular Pathways in Congenital Rare Disorders Affecting the Brain and MuscleR01NS109149 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MANZINI, M. CHIARA · 2019 to 2023
$1.7M
Training in Translating Neuroscience to TherapiesT32NS115700 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MOURADIAN, M. MARAL · 2021 to 2025
$1.4M
Medical Research Council MRC/N010035/1NINDS NIH HHS R01 NS109149NINDS NIH HHS T32 NS115700Wellcome Trust 105616/Z/14/Z
6 · The paper itself

Abstract

One hurdle in the development of zebrafish models of human disease is the presence of multiple zebrafish orthologs resulting from whole genome duplication in teleosts. Mutations in inositol polyphosphate 5-phosphatase K (INPP5K) lead to a syndrome characterized by variable presentation of intellectual disability, brain abnormalities, cataracts, muscle disease, and short stature. INPP5K is a phosphatase acting at position 5 of phosphoinositides to control their homeostasis and is involved in insulin signaling, cytoskeletal regulation, and protein trafficking. Previously, our group and others have replicated the human phenotypes in zebrafish knockdown models by targeting both INPP5K orthologs inpp5ka and inpp5kb. Here, we show that inpp5ka is the more closely related orthologue to human INPP5K. While both inpp5ka and inpp5kb mRNA expression levels follow a similar trend in the developing head, eyes, and tail, inpp5ka is much more abundantly expressed in these tissues than inpp5kb. In situ hybridization revealed a similar trend, also showing unique localization of inpp5kb in the pineal gland and retina indicating different transcriptional regulation. We also found that inpp5kb has lost its catalytic activity against its preferred substrate, PtdIns(4,5)P

Indexed as

Gene Expression RegulationZebrafishAnimalsHumansInositolInositol Polyphosphate 5-PhosphatasesMutationPhosphoric Monoester HydrolasesZebrafish ProteinsInositolInositol Polyphosphate 5-Phosphatasesinpp5ka protein, zebrafishinpp5kb protein, zebrafishPhosphoric Monoester HydrolasesZebrafish ProteinsGene duplicationInositol phosphataseINPP5KZebrafish

Identifiers

PMID37184573
PMCPMC10239392
OpenAlexW4376630692

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.