Evidence mapPaperPMID 37189652Full record

ArticleBiomedicines2023

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer's Disease Brain by Autoradiography Using [

Rommani Mondal, Yasmin K Sandhu, Vallabhi M Kamalia, Brooke A Delaney, Amina U Syed, Grace A H Nguyen, Taylor R Moran, Roz R Limpengco, Christopher Liang, Jogeshwar Mukherjee

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Evaluation of [Acta neuropathologica communications · 2026
    Article
  2. Article
  3. Synthesis and Evaluation of Radioiodinated [Journal of labelled compounds & radiopharmaceuticals · 2026
    Article
  4. Quantification of Alzheimer disease neuropathology using tissue microarrays.Journal of neuropathology and experimental neurology · 2025
    Article
  5. Article
  6. [Synapse (New York, N.Y.) · 2025
    Article
  7. Reduction in [Brain research · 2025
    Article
  8. [Biomolecules · 2025
    Article
  9. Article
  10. Evaluation of [Receptors (Basel, Switzerland) · 2025
    Article
  11. Article
  12. [International journal of molecular sciences · 2024
    Article
  13. Article
  14. [Neurology international · 2024
    Article
  15. Article
  16. [Molecules (Basel, Switzerland) · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rommani MondalPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Yasmin K SandhuPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Vallabhi M KamaliaPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Brooke A DelaneyPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Amina U SyedPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Grace A H NguyenPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Taylor R MoranPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Roz R LimpengcoPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1009-877X
University of California, Irvine · US

Funding

National Institute of Health AG029479NIA NIH HHS R01 AG029479
6 · The paper itself

Abstract

High-resolution scans of immunohistochemical (IHC) stains of Alzheimer's disease (AD) brain slices and radioligand autoradiography both provide information about the distribution of Aβ plaques and Tau, the two common proteinopathies in AD. Accurate assessment of the amount and regional location of Aβ plaques and Tau is essential to understand the progression of AD pathology. Our goal was to develop a quantitative method for the analysis of IHC-autoradiography images. Postmortem anterior cingulate (AC) and corpus callosum (CC) from AD and control (CN) subjects were IHC stained with anti-Aβ for Aβ plaques and autoradiography with [

Indexed as

[124I]IPPI[125I]IBETA[125I]IPPI[18F]FlotazaAlzheimer’s diseaseautoradiographyAβ amyloid plaquesneurofibrillary tanglesPET imagingQuPathtau

Identifiers

PMID37189652
PMCPMC10136263
OpenAlexW4361212883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.